distribution of demographic and SLE characteristics according to sides effects and disease flares after vaccination
| Side effects (n=119) | No side effects (n=333) | p-value (<0.05) | Disease flare (n=19) | No disease flare (n=430) | p-value (<0.05) | |
|---|---|---|---|---|---|---|
| Age, years, median (IQR) | 46 (33.5-54) | 48 (35.7-57) | 0.18 | 52 (39.5-56.0) | 48 (35.0-56.9) | 0.849 |
| Disease duration, months, median (IQR) | 138 (76-262) | 126 (73-193) | 0.30 | 144 (122-242) | 127 (73-195) | 0.249 |
| MSK, % | 84.9 | 84.4 | 1.00 | 78.9 | 84.8 | 0.514 |
| Mucocutaneus, % | 71.4 | 62.8 | 0.094 | 57.9 | 64.5 | 0.624 |
| Renal, % | 42.0 | 52.3 | 0.069 | 52.6 | 49.4 | 0.819 |
| NPSLE, % | 13.4 | 9 | 0.215 | 5.3 | 10.4 | 0.708 |
| Cardiopulmonary % | 22.7 | 19.8 | 0.510 | 26.3 | 20.3 | 0.562 |
| Hematological, % | 32.8 | 33 | 1.00 | 42.1 | 32.6 | 0.455 |
| Constitutional symptoms % | 48.7 | 30 | 0.0003* | 26.3 | 35.3 | 0.473 |
| Gastrointestinal % | 4.2 | 3.3 | 0.772 | 5.3 | 3.5 | 0.503 |
| Ophthalmic % | 0.8 | 3.3 | 0.197 | 0 | 2.8 | 1.00 |
| Secondary APS % | 10.9 | 10.5 | 0.864 | 5.3 | 10.9 | 0.708 |
| aPL positivity % | 26.2 | 33.6 | 0.137 | 26.3 | 31.9 | 0.802 |
| Anti-dsDNA positivity % | 30.7 | 27.4 | 0.545 | 55.6 | 27.1 | 0.0142* |
| ESR, mm/h, median (IQR) | 14 (7-19) | 13 (7-22) | 0.730 | 19 (10-24) | 13 (7-21) | 0.125 |
| CRP, mg/dL, median (IQR) | 0.5 (0.1-0.5) | 0.5 (0.3-0.6) | 0.312 | 0.42 (0.13-0.50) | 0.50 (0.30-0.5) | 0.464 |
| Urinary abnormalities, % | 9.2 | 21.9 | 0.0023 | 21.1 | 18.5 | 0.764 |
| Moderate or high DAS before vaccine, % | 16 | 9.3 | 0.060 | 26.3 | 10.4 | 0.0474* |
| No therapy before vaccine, % | 0 | 3.6 | 0.0419* | 0 | 2.8 | 1.00 |
| At least 1 immunosuppressant, % | 63 | 46.8 | 0.0027* | 73.7 | 50.1 | 0.059 |
| Mycophenolate, % | 31.9 | 23.1 | 0.066 | 42.1 | 24.7 | 0.106 |
| Methotrexate, % | 5.9 | 6.6 | 1.00 | 5.3 | 6.5 | 1.00 |
| Belimumab, % | 21.8 | 13.5 | 0.0396* | 36.8 | 14.8 | 0.0184* |
| Rituximab ever, % | 11.8 | 13.5 | 0.751 | 5.3 | 13.4 | 0.490 |
| Prednisone, % | 74.8 | 70 | 0.347 | 78.9 | 70.9 | 0.607 |