All patients† | Patients <60 years‡ | Patients ≥60 years‡ | ||||||||||
β | P value | 95% CI | βst | β | P value | 95% CI | βst | β | P value | 95% CI | βst | |
Neutralisation capacity | ||||||||||||
TBV | 0.00 | 0.976 | −0.20 to 0.19 | 0.00 | −0.05 | 0.749 | −0.37 to 0.27 | −0.06 | 0.04 | 0.807 | −0.26 to 0.33 | 0.03 |
TAV | 0.19 | 0.005 | 0.06 to 0.32 | 0.30 | 0.09 | 0.301 | −0.09 to 0.28 | 0.20 | 0.24 | 0.012 | 0.06 to 0.43 | 0.32 |
TBV ≥10 days | −0.85 | 0.367 | −2.73 to 1.02 | −0.08 | −0.36 | 0.789 | −3.12 to 2.40 | −0.05 | −1.98 | 0.094 | −4.31 to 0.35 | −0.13 |
TAV ≥10 days | 2.00 | 0.008 | 0.53 to 3.47 | 0.27 | −0.22 | 0.833 | −2.34 to 1.91 | −0.04 | 2.91 | 0.001 | 1.29 to 4.53 | 0.36 |
TBV+TAV | 0.13 | 0.035 | 0.01 to 0.25 | 0.25 | 0.04 | 0.626 | −0.13 to 0.22 | 0.11 | 0.18 | 0.039 | 0.01 to 0.35 | 0.29 |
Anti-RBD-IgG | ||||||||||||
TBV | 0.80 | 0.244 | −0.56 to 2.15 | 0.09 | 0.47 | 0.575 | −1.24 to 2.17 | 0.10 | 1.26 | 0.236 | −0.86 to 3.39 | 0.12 |
TAV | 1.02 | 0.016 | 0.19 to 1.84 | 0.19 | 0.11 | 0.739 | −0.56 to 0.78 | 0.04 | 1.63 | 0.036 | 0.12 to 3.14 | 0.22 |
TBV ≥10 days | −1.86 | 0.777 | −14.96 to 11.24 | −0.02 | 0.49 | 0.950 | −15.49 to 16.47 | 0.01 | −6.43 | 0.323 | −19.43 to 6.57 | −0.05 |
TAV ≥10 days | 13.70 | 0.004 | 4.60 to 22.79 | 0.21 | −2.53 | 0.583 | −11.96 to 6.90 | −0.07 | 20.03 | 0.005 | 6.57 to 33.50 | 0.26 |
TBV+TAV | 0.95 | 0.003 | 0.33 to 1.58 | 0.22 | 0.21 | 0.487 | −0.41 to 0.84 | 0.09 | 1.51 | 0.019 | 0.26 to 2.77 | 0.26 |
Significant results are in bold.
*One patient who did not hold MTX could not recall on which exact day MTX was taken and was therefore only considered for calculations of TBV+TAV (=7 days).
†Adjusted for female, age, MTX monotherapy, MTX+prednisolone, MTX combination±prednisolone, vaccine interval.
‡Adjusted for female, MTX monotherapy, MTX+prednisolone, MTX combination±prednisolone, vaccine interval. β (unstandardised beta-coefficient); βst (standardised beta-coefficient); TBV (time before vaccination), time between last MTX intake and vaccination; TAV (time after vaccination), time between vaccination and re-intake of MTX; TBV+TAV, MTX interval at the time of vaccination.
MTX, methotrexate.