Table 7

Adverse events of special interest possibly/probably related to COVID-19 vaccination among patient with non-inflammatory RMDs

AE type	Severity of AE	Outcome of AE	COVID-19 vaccine	RMD	RMD medication	Medication held or reduced
Cardiovascular –arterial hypertension	Serious (important medical event)	Recovered/resolved with sequelae	Pfizer	OA	None	NA
Cardiovascular –arterial hypertension	Non-serious	Recovered/resolved without sequelae	Pfizer	Other mechanical RMD	None	NA
Dermatological – pruritus, injection site reaction, redness and burning	Non-serious	Recovered/resolved without sequelae	Moderna	OA	None	NA
	Non-serious	Recovered/resolved without sequelae	Pfizer	OA	None	NA
Gastrointestinal – liver injury	Non-serious	Ongoing/continuing	Pfizer	OA	None	NA
	Non-serious	UNK	Moderna	Osteoporosis	None	No
	Serious (important medical event)	Ongoing/continuing	AZ	Fibromyalgia	None
General conditions – hot flush, anxiety, lowered body temperature, loss and lack of appetite and night sweats	Non-serious	Recovered/resolved without sequelae	AZ	OA	None	NA
Immunological – arthritis	Non-serious	Recovered/resolved without sequelae	Pfizer	Other mechanical RMD	None	NA
	Non-serious	Recovered/resolved without sequelae	Pfizer	Osteoporosis	None	NA
	Serious (important medical event)	Ongoing/continuing	AZ	OA	None	NA
	Serious (important medical event)	Recovered/resolved with sequelae	Pfizer	OA	None	NA
	Non-serious	Ongoing/continuing	Moderna	Other mechanical RMD	None	NA
Immunological – skin and mucosal	Non-serious	Recovered/resolved without sequelae	AZ	OA	None	NA
Immunological – vasculitides	Serious (hospitalisation)	Recovered/resolved without sequelae	Moderna	OA	None	NA
Immunological – vasculitides	Serious (important medical event)	Ongoing/continuing	Pfizer	OA	None	NA
Malaise, fatigue and insomnia	Non-serious	Recovered/resolved without sequelae	Pfizer	OA	Colchicine	No
Lymphadenopathy	Non-serious	Recovered/resolved without sequelae	Pfizer	OA	None	NA
Lymphadenopathy	Non-serious	Recovered/resolved without sequelae	Pfizer	Osteoporosis	None	NA
Neurological – drowsiness, vertigo, dizziness, nausea, tinnitus, migraine, hallucination and hemiparesis	Non-serious	Recovered/resolved without sequelae	Moderna	Osteoporosis	None	NA
	Non-serious	Recovered/resolved without sequelae	Moderna	OA	None	NA
	Non-serious	Recovered/resolved without sequelae	Pfizer	Other mechanical RMD	None	NA
	Non-serious	Recovered/resolved without sequelae	Pfizer	Gout	None	NA
	Non-serious	Recovered/resolved without sequelae	AZ	Other mechanical RMD	None	NA
	Serious (important medical event)	Recovered/resolved without sequelae	Pfizer	Fibromyalgia	None	NA
	Serious (important medical event)	Recovered/resolved without sequelae	Pfizer	Fibromyalgia	None	NA
Other possible cardiac symptoms – ankle oedema, dyspnoea and dry cough	Non-serious	Recovered/resolved without sequelae	Pfizer	OA	HCQ	No
	Serious (hospitalisation)	Recovered/resolved without sequelae	Pfizer	Osteoporosis	None	NA
Pain/pain syndromes	Non-serious	Recovered/resolved without sequelae	AZ	OA	None	NA
Pain/pain syndromes	Non-serious	Recovered/resolved without sequelae	Pfizer	OA	None	NA
Tendons and joints – tendinopathy, frozen shoulder and carpal tunnel syndrome	Non-serious	Recovered/resolved without sequelae	AZ	Osteoporosis	None	NA
	Serious (Important medical event)	Ongoing/continuing	AZ	Chronic mechanical back pain	None	NA
Viral infections – herpes, herpes zoster and shingles	Non-serious	Recovered/resolved without sequelae	Pfizer	OA	None	NA
Viral infections – influenza, flu-like episodes, rhinitis, cough and cold	Non-serious	Recovered/resolved without sequelae	AZ	Osteoporosis	None	NA
Other – epistaxis	Non-serious	Recovered/resolved without sequelae	AZ	OA	None	NA
Other (UNK)	Non-serious	Recovered/resolved without sequelae	Moderna	Fibromyalgia	None	NA
Other (UNK)	Non-serious	Recovered/resolved without sequelae	Pfizer	Fibromyalgia	None	NA

*Immunosuppressive or immunomodulatory medication.
AZ, Oxford/AstraZeneca; HCQ, hydroxychloroquine; OA, osteoarthritis; RMD, rheumatic and musculoskeletal disease; UNK, unknown/missing.