β* | 95% CI | P value | |
Corticosteroids≤10 mg/day | −42 | −93 to 9.0 | 0.10 |
Corticosteroids>10 mg/day | −135 | −230 to -39 | 0.007 |
Hydroxychloroquine | −34 | −110 to 43 | 0.4 |
Azathioprine | −71 | −233 to 92 | 0.4 |
Belimumab | 9.6 | −105 to 125 | 0.9 |
Mycophenolate mofetil | −146 | −224 to -68 | <0.001 |
Methotrexate | −121 | −202 to -41 | 0.004 |
Other immunosuppressor | 203 | 5.6 to 401 | 0.044 |
Marginal zone B lymphocytes, day 1 (%) | −0.22 | −2.7 to 2.3 | 0.9 |
Autoreactive B lymphocytes, day 1 (%) | −1.5 | −4.3 to 1.3 | 0.3 |
Naïve B lymphocytes, day 1 (%) | 2.5 | 0.87 to 4.0 | 0.003 |
Double negative B lymphocytes, day 1 (%) | 3.8 | −2.2 to 9.9 | 0.2 |
Memory B lymphocytes, day 1 (%) | −0.57 | −2.3 to 1.2 | 0.5 |
*See the Methods section. Autoreactive B cells (CD21lowCD38low); double negative B cells (CD27-IgD-); marginal zone B cells (CD27+IgD+); memory B cells (CD27+IgD-); naïve B cells (CD27-IgD+). B cell subset frequencies are measured in total B cells.