Table 4

Baseline B cell predictors of day 42 anti-SARS-CoV-2 RBD IgG titres according to linear regression model

β*95% CIP value
Corticosteroids≤10 mg/day−42−93 to 9.00.10
Corticosteroids>10 mg/day−135−230 to -390.007
Hydroxychloroquine−34−110 to 430.4
Azathioprine−71−233 to 920.4
Belimumab9.6−105 to 1250.9
Mycophenolate mofetil−146−224 to -68<0.001
Methotrexate−121−202 to -410.004
Other immunosuppressor2035.6 to 4010.044
Marginal zone B lymphocytes, day 1 (%)−0.22−2.7 to 2.30.9
Autoreactive B lymphocytes, day 1 (%)−1.5−4.3 to 1.30.3
Naïve B lymphocytes, day 1 (%)2.50.87 to 4.00.003
Double negative B lymphocytes, day 1 (%)3.8−2.2 to 9.90.2
Memory B lymphocytes, day 1 (%)−0.57−2.3 to 1.20.5
  • *See the Methods section. Autoreactive B cells (CD21lowCD38low); double negative B cells (CD27-IgD-); marginal zone B cells (CD27+IgD+); memory B cells (CD27+IgD-); naïve B cells (CD27-IgD+). B cell subset frequencies are measured in total B cells.