Inconsistencies in the frequencies of the top associated amino acids from Guo et al 1
Amino acids | Guo et al | OR‡ | Other studies* | |||
Frequency† | Hong Kong Chinese | Koreans§ | Japanese | |||
Controls | Patients with RA | n=1064 | n=1209 | n=3078 | ||
DQα1:160D | 0.20 | 0.36 | 2.36 | 0.21 | 0.22 | 0.31 |
DQα1:160A | 0.22 | 0.37 | 2.27 | 0.78 | 0.76 | 0.66 |
DQα1:160S | 0.02 | 0.01 | 0.01 | 0.02 | 0.03 | |
DRβ1:37N | 0.23 | 0.23 | 0.49 |
*Taken from the Allele Frequencies Net Database (http://allelefrequencies.net).
†Frequencies taken from Guo et al. Figure 3 and supplementary tables 3, 5 and 8 for DQα1 amino acids and from supplementary tables 4, 6 and 8 for DRβ1:37N.
‡OR reported in pages 775 and 776 of Guo et al for DQα1 and DRβ1:37N, respectively.
§Results for Koreans were combined from four studies.
RA, rheumatoid arthritis.