Table 2

Rheumatic and musculoskeletal disease information

Primary RMD diagnosisInflammatory RMDs4604 (90)
Inflammatory joint diseases2979 (58)
Rheumatoid arthritis1686 (33)
Axial spondyloarthritis (including ankylosing spondylitis)573 (11)
Psoriatic arthritis505 (10)
Other peripheral spondyloarthritis (including reactive arthritis)114 (2)
Juvenile idiopathic arthritis, not systemic23 (<1)
Systemic juvenile idiopathic arthritis7 (<1)
Other inflammatory arthritis70 (1)
Connective tissue diseases928 (18)
Systemic lupus erythematosus367 (7)
Primary anti-phospholipid syndrome26 (1)
Sjogren's syndrome223 (4)
Systemic sclerosis162 (3)
Idiopathic inflammatory myopathy (myositis)69 (1)
Mixed connective tissue disease37 (1)
Undifferentiated connective tissue disease43 (1)
Ehlers-Danlos syndromes1 (<1)
Vasculitis593 (12)
Large vessel vasculitis – Takayasu arteritis14 (<1)
Large vessel vasculitis – giant cell arteritis141 (3)
Polymyalgia rheumatica239 (5)
Medium-vessel vasculitis (polyarteritis nodosa, Kawasaki disease)11 (<1)
ANCA-associated vasculitis (MP, GPA, EGPA)127 (2)
Immune complex small vessel vasculitis7 (<1)
Behcet's syndrome33 (1)
Other vasculitis21 (<1)
Other immune-mediated inflammatory diseases106 (2)
Monogenic autoinflammatory syndrome13 (<1)
Non-monogenic autoinflammatory syndrome12 (<1)
IgG4-related disease16 (<1)
Sarcoidosis56 (1)
Relapsing polychondritis7 (<1)
Chronic recurrent multifocal osteomyelitis2 (<1)
Non-inflammatory RMDs517 (10)
Gout or other crystal arthritis62 (1)
Osteoporosis112 (2)
Osteoarthritis240 (5)
Fibromyalgia36 (1)
Chronic mechanical back pain16 (<1)
Radiculopathy or regional pain7 (<1)
Other mechanical RMD (eg, tendinitis and bursitis)44 (1)
Rheumatic disease activity (only applicable to patients with inflammatory RMD; n=4604)Remission or inactive disease1867 (41)
Minimal or low disease activity1276 (28)
Moderate disease activity610 (13)
Severe or high disease activity76 (2)
Missing/unknown775 (17)
Medication exposure at the time of vaccination (only applicable to patients with inflammatory RMD; n=4604)csDMARDS2497 (54)
Antimalarials (including hydroxychloroquine and chloroquine)568 (12)
Held before vaccination2
Reduced before vaccination1
Held after vaccination3
Reduced after vaccination2
Leflunomide211 (5)
Held before vaccination7
Reduced before vaccination1
Held after vaccination2
Held before vaccination58
Reduced before vaccination3
Held after vaccination90
Reduced after vaccination1
Sulfasalazine161 (4)
Held before vaccination1
Held after vaccination1
Reduced after vaccination1
bDMARDS1944 (42)
Abatacept103 (2)
Held before vaccination5
Held after vaccination3
Belimumab32 (1)
Held before vaccination2
Rituximab260 (6)
Held before vaccination18
Reduced before vaccination2
Held after vaccination1
Reduced after vaccination1
IL-1 inhibitors (including anakinra, canakinumab, rilonacept)19 (<1)
IL-6 inhibitors (including tocilizumab and sarilumab)222 (5)
Held before vaccination16
Held after vaccination4
Reduced after vaccination1
IL-12/23 inhibitors (including ustekinumab)34 (1)
Held before vaccination2
IL-23 inhibitors (guselkumab, risankizumab and tildrakizumab)2 (<1)
IL-17 inhibitors (including secukinumab, ixekizumab and brodalumab)99 (2)
Held before vaccination4
Held after vaccination4
Reduced after vaccination1
TNF-inhibitors (including adalimumab, certolizumab, etanercept, golimumab, infliximab and biosimilars)1173 (25)
Held before vaccination67
Reduced before vaccination5
Held after vaccination29
Reduced after vaccination2
tsDMARDS175 (4)
Apremilast13 (<1)
JAK inhibitors (including tofacitinib, baricitinib and upadacitinib)162 (4)
Held before vaccination5
Reduced before vaccination1
Held after vaccination10
Immunosuppressants1621 (35)
Glucocorticoids (systemic)1385 (30)
Held before vaccination6
Reduced before vaccination6
Held after vaccination6
Reduced after vaccination9
Azathioprine/6-mercaptopurine88 (2)
Held before vaccination2
Cyclosporine15 (<1)
Held before vaccination2
Reduced before vaccination1
Cyclophosphamide8 (<1)
Mycophenolate mofetil/mycophenolic acid123 (3)
Held before vaccination6
Held after vaccination2
Reduced after vaccination1
Tacrolimus2 (<1)
Other78 (2)
Intravenous immunoglobulin15 (<1)
Held after vaccination1
Antifibrotics (pirfenidone and nintedanib)5 (<1)
Thalidomide/lenalidomide2 (<1)
Colchicine24 (<1)
Denosumab26 (1)
Mepolizumab4 (<1)
Pembrolizumab1 (<1)
Vedolizumab1 (<1)
Unknown/missing43 (1)
None393 (9)
  • All values are n (%) unless stated otherwise.

  • ANCA, anti-neutrophil cytoplasmic antibody; bDMARDs, biological disease-modifying antirheumatic drugs; csDMARDs, conventional synthetic disease-modifying antirheumatic drugs; EGPA, eosinophilic granulomatosis with polyangiitis; GPA, granulomatosis with polyangiitis; IL, interleukin; JAK, Janus kinase; MP, microscopic polyangiitis; TNF, tumour necrosis factor; tsDMARDs, targeted synthetic disease-modifying antirheumatic drug.