Incidence rates of the first flare in patients with SLE who maintained, reduced or discontinued HCQ
| HCQ reduction n=564 | HCQ maintenance n=778 | HCQ discontinuation n=389 | HCQ maintenance n=577 | |
| First flare (any) | ||||
| Number of events (%) | 444 (78.7) | 413 (53.1) | 280 (72.0) | 292 (50.6) |
| Therapy augmentation only | 399 (70.7) | 325 (41.8) | 252 (64.8) | 239 (41.4) |
| Increase in disease activity only | 61 (17.0) | 127 (16.3) | 68 (17.5) | 81 (14.0) |
| Hospitalisation only | 1 (0.2) | 1 (0.2) | 0 | 2 (0.5) |
| Total person-years in follow-up | 1110.2 | 1294.7 | 677.9 | 973.4 |
| Crude rate/100 person-years (95% CI) | 40.0 (36.4 to 43.9) | 31.9 (29.0 to 35.1) | 41.3 (36.7 to 46.4) | 30.0 (26.7 to 33.6) |
HCQ, hydroxychloroquine; ;SLE, systemic lupus erythematosus.