miRNA ID | MIMATID | FC | P value | ||
UP | hsa-miR-653-5p | MIMAT0003328 | 2.4544 | 0.0005 | Human |
hsa-miR-224-5p | MIMAT0000281 | 2.0148 | 0.0027 | ||
hsa-miR-206 | MIMAT0000462 | 2.0056 | 0.0037 | ||
hsa-miR-558 | MIMAT0003222 | 1.9013 | 0.0072 | ||
hsa-miR-573 | MIMAT0003238 | 1.8562 | 0.0222 | ||
hsa-miR-593 | MIMAT0003261 | 1.7143 | 0.0433 | ||
hsa-miR-425-3p | MIMAT0001343 | 1.6772 | 0.0133 | ||
hsa-miR-189 | MIMAT0000079 | 1.5837 | 0.0144 | ||
hsa-miR-525* | MIMAT0002839 | 1.4999 | 0.0152 | ||
hsa-miR-200a | MIMAT0000682 | 1.4419 | 0.0055 | ||
hsa-miR-601 | MIMAT0003269 | 1.4341 | 0.0100 | ||
hsa-miR-100 | MIMAT0000098 | 1.4236 | 0.0054 | ||
hsa-miR-608 | MIMAT0003276 | 1.4009 | 0.0245 | ||
hsa-miR-569 | MIMAT0003234 | 1.3756 | 0.0399 | ||
hsa-miR-376a | MIMAT0000729 | 1.1229 | 0.0166 | ||
hsa-miR-627 | MIMAT0003296 | 1.0759 | 0.0329 | ||
DOWN | hsa-miR-302b | MIMAT0000715 | −1.1783 | 0.0449 | |
hsa-miR-98 | MIMAT0000096 | −1.2594 | 0.0329 | ||
hsa-miR-520e | MIMAT0002825 | −1.4332 | 0.0287 | ||
hsa-miR-340 | MIMAT0004692 | −1.6206 | 0.0363 | ||
hsa-miR-566 | MIMAT0003230 | −1.6358 | 0.0155 | ||
hsa-miR-423 | MIMAT0001340 | −1.7271 | 0.0330 | ||
hsa-miR-519e* | MIMAT0002828 | −1.8331 | 0.0130 | ||
hsa-miR-432 | MIMAT0002814 | −1.8483 | 0.0144 | ||
hsa-miR-31 | MIMAT0000089 | −1.9111 | 0.0111 | ||
hsa-miR-411-5p | MIMAT0003329 | −2.1903 | 0.0013 | ||
hsa-miR-187-3p | MIMAT0000262 | −2.1927 | 0.0037 | ||
hsa-miR-27a-3p | MIMAT0000084 | −2.2675 | 0.0034 | ||
hsa-miR-600 | MIMAT0003268 | −2.3197 | 0.0033 | ||
UP | ebv-miR-BHRF1-2* | MIMAT0000996 | 1.4385 | 0.0229 | Viral |
ebv-miR-BART1-5p | MIMAT0000999 | 1.3104 | 0.0217 | ||
ebv-miR-BART14-3p | MIMAT0003426 | 1.1894 | 0.0376 | ||
DOWN | ebv-miR-BART6-3p | MIMAT0003415 | −1.6170 | 0.0069 | |
kshv-miR-K12-7 | MIMAT0002187 | −1.6632 | 0.0222 | ||
kshv-miR-K12-9 | MIMAT0002185 | −1.8083 | 0.0187 | ||
kshv-miR-K12-1 | MIMAT0002182 | −2.0371 | 0.0026 |
miRNAs in bold italic were selected for the technical validation phase. miRNAs in bold were included in the FAA. Only human miRNAs were taken into account (indicated by ‘hsa’ prefix) considering that the observed presence of DE miRNA sequences originating from DNA viruses has been widely found in plasma samples (also from healthy subjects) but may only account for infection latency and reportedly failed to associate with active infectious state. P values were calculated by two-tailed Student’s t-test.
BS, Behçet’s syndrome; DE ci-miRNA, differentially expressed circulating microRNA; DOWN, downregulated miRNAs; n=34 (16 patients with BS vs 18 HCs); FAA, Funcional annotation analysis; FC, normalised expression fold change values in log2 scale; HC, healthy control; MIMATID, unique mature miRNA accession number; p, Limma (linear models for microarray data) differential expression t-test p value; UP, upregulated miRNAs.