Table 1

Unadjusted sample characteristics stratified by development of a cardiovascular event (CVE) measured at registry enrolment*

Variable	No CVE (N=18 796)		CVE (N=1106)		P value
Variable	Mean	SD	Mean	SD
Age (years)	57.82	13.36	65.44	11.07	<0.001
Duration of rheumatoid arthritis (years)	8.84	9.42	11.56	10.76	<0.001
mHAQ	0.32	0.42	0.38	0.47	<0.001
CDAI	12.73	12.50	14.04	12.84	0.001
28 Joint Count: Tender	3.93	5.81	4.44	6.39	0.005
28 Joint Count: Swollen	3.81	5.39	4.18	5.33	0.028
Patient Global Assessment (0–100 scale)	28.95	26.08	31.71	26.44	0.001
Physician Global Assessment (0–100 scale)	21.76	20.38	23.75	20.53	0.002
Body mass index (kg/m²)	29.44	7.14	29.60	7.00	0.468
	N	%	N	%
Gender					<0.001
Male	4134	22.0	369	33.4
Female	14 662	78.0	737	66.6
Race					0.202
Asian	286	1.5	12	1.1
Black	1184	6.3	55	5
Mixed race	223	1.2	14	1.3
Native American	122	0.6	6	0.5
Other	105	0.6	3	0.3
Pacific Islander	21	0.1	2	0.2
Unknown	132	0.7	3	0.3
White	16 723	89.0	1011	91.4
History of cardiovascular disease					<0.001
Yes	1457	7.8	277	25.0
History of diabetes					<0.001
Yes	1502	8.0	176	15.9
History of hyperlipidaemia					<0.001
Yes	4154	22.1	333	30.1
History of hypertension					<0.001
Yes	5583	29.7	511	46.2
Smoking status					0.001
Never	11 330	60.3	604	54.6
Previous	4946	26.3	339	30.7
Current	2520	13.4	163	14.7
Exercise					<0.001
None	5879	31.3	390	35.3
1–2 times/week	5313	28.3	277	25.0
3–4 times/week	4054	21.6	213	19.3
5–6 times/week	1376	7.3	68	6.1
Daily	1748	9.3	141	12.7
Not sure	426	2.3	17	1.5
Statin use					<0.001
Yes	3750	20.0	303	27.4
NSAID use					0.024
Yes	10 272	54.6	643	58.1
Analgesic use					<0.001
Yes	8516	45.3	565	51.1
Prior or current biologic/targeted DMARD use					0.815
Yes	8633	45.9	504	45.6
Prior or current conventional DMARDs					<0.001
Yes	16 447	87.5	1019	92.1
Prior or current methotrexate use					<0.001
Yes	14 027	74.6	893	80.7

*Patients were enrolled with prevalent disease.
CDAI, Clinical Disease Activity Index; DMARDs, disease-modifying antirheumatic drugs; mHAQ, modified Health Assessment Questionnaire; NSAID, non-steroidal anti-inflammatory drug.