Table 1

Data characteristics, and effect of RA and MUC5B on risk of ILD

Individuals without RAIndividuals with RA
Non-carriers of MUC5B promoter variantCarriers of MUC5B promoter variantNon-carriers of MUC5B promoter variantCarriers of MUC5B promoter variant
N231 86055 24354311438
ILD cases100771115196
ILD cases in men/women600/407461/25070/8141/55
Age at ILD onset, men/women (mean (SD))66.9 (10.4)/63.0 (13.3)67.9 (8.3)/65.3 (11.1)65.6 (9.1)/64.1 (9.2)68.5 (7.4)/66.9 (8.7)
Risk of ILD in women and men
 Lifetime risk, % (95% CI)1.5 (1.3–1.6)4.4 (4.1–4.8)6.1 (5.0–7.2)16.8 (13.1–20.2)
 HR (95% CI)Reference2.49 (2.25–2.75)4.99 (4.20–5.94)9.84 (7.96–12.2)
 P value1.24×10−71 2.67×10−74 4.40×10−99
Risk of ILD in men
 Lifetime risk, % (95% CI)1.7 (1.6–1.9)5.6 (5.1–6.2)9.0 (6.7–11.2)20.9 (14.1–27.1)
 HR (95% CI)Reference2.63 (2.31–2.98)5.72 (4.46–7.34)8.23 (5.96–11.4)
 P value2.04×10−50 6.81×10−43 1.56×10−37
Risk of ILD in women
 Lifetime risk, % (95% CI)1.1 (1.0–1.3)3.1 (2.6–3.5)4.7 (3.6–5.9)14.5 (10.2–18.6)
 HR (95% CI)Reference2.26 (1.92–2.66)4.49 (3.53–5.70)11.9 (8.96–15.8)
 P value1.46×10−22 1.31×10−34 7.86×10−66
  • ILD, interstitial lung disease; RA, rheumatoid arthritis.