Incidence rates of cardiovascular events in veterans with rheumatoid arthritis (per 1000 person-years)
| Event category* | N | Follow-up time (PY) | Mean time to event, years | Incidence rates (per 1000 PY) | IRR (95% CI) | |
| MTX ever-exposed | MTX never-exposed | |||||
| Composite | 378 | 10 360 | 3.42 | 33.05 | 39.88 | 0.83 (0.67 to 1.02) |
| HF hospitalisation | 87 | 10 956 | 3.47 | 5.17 | 10.66 | 0.48 (0.30 to 0.77) |
| MACE | 342 | 10 443 | 3.45 | 30.32 | 35.14 | 0.86 (0.69 to 1.07) |
| CAD | 151 | 10 605 | 3.08 | 13.50 | 14.97 | 0.90 (0.65 to 1.26) |
| Stroke | 66 | 10 934 | 3.36 | 6.13 | 5.95 | 1.03 (0.62 to 1.72) |
| CVD Death | 167 | 11 098 | 3.99 | 13.00 | 17.03 | 0.76 (0.55 to 1.05) |
Values listed in bold indicate p<0.05.
*MACE is a composite of outcomes included in CAD, stroke and CVD death. CAD includes acute myocardial infarction, percutaneous coronary intervention or coronary artery bypass.
.CAD, coronary artery disease; CVD, cardiovascular disease; HF, heart failure; IRR, incidence rate ratio; MACE, major adverse cardiovascular event; MTX, methotrexate; PY, person years; RA, rheumatoid arthritis.