Table 2

Humoral response—univariate and multivariate analyses

(A) Univariate analyses
Humoral response Positive Negative P value
Age mean(SD)56.9 (13.3)62.05 (11.6)0.024
Gender —female157270.64
Disease duration mean (SD)10.7(7.3)13.2(7.3)0.032
Type of rheumatic disease
Therapy, n
 Mycophenolate mofetil1790.004
Biological/targeted DMARDs148300.056
 B-cell depleting (Anti-CD-20)24240.0001
 Anti-TNF anti-interleukins abatacept63 39 50 1 30.02 0.023 0.086
 Anti-JAK agents900.618
Combined therapy (without rituximab)6550.043
(B) Multivariate logistic regression analysis
Variables P value OR 95% CI lower to upper
Age0.0840.9650.927 to 1.005
Disease duration0.0430.9480.900 to 0.998
MMF0.00010.0640.017 to 0.239
Anti-CD200.00010.0330.012 to 0.092
Abatacept0.0030.070.012 to 0.399
  • csDMARDs, conventional synthetic disease-modifying antirheumatic drugs; CTD, connective tissue diseases; IJD, inflammatory joint diseases; JAK, janus kinase; MMF, mycophenolate mofetil.