Association between ACL IgG and disease severity, platelet counts and need for anticoagulation
| Cohort | All | aCL IgG positive | aCL IgG negative | |
| N | 42 | 20 | 22 | |
| Age | Mean (CI) | 58.2 (62.7 to 54.1) | 55.9 (62.9 to 49) | 60.7 (66.4 to 55) |
| Sex | N male (%) | 29/42 (69) | 13/20 (65) | 16/22 (73) |
| Days from symptom onset to ICU | Mean (CI) | 6 (8.3 to 3.7) | 8.7 (12.8 to 4.6) | 3.4 (5.4 to 1.5) |
| APACHE II on ICU admission | Mean (CI) | 25.3 (27.6 to 22.9) | 25.7 (28.5 to 22.9) | 24.9 (28.8 to 20.9) |
| Mean of SOFA score for first 3 days | Mean (CI) | 9.6 (10.7 to 8.5) | 10.6 (12.2 to 9.1) | 8.7 (10.3 to 7) |
| Mean of SOFA score for first 7 days | Mean (CI) | 8.9 (10.1 to 7.8) | 10 (11.7 to 8.4) | 8 (9.5 to 6.4) |
| ICU days (censored) | Mean (CI) | 14.1 (17.3 to 10.8) | 16.6 (21.9 to 11.3) | 12.1 (16.5 to 7.6) |
| Death in ICU | N (%) | 13/42 (31) | 8/20 (40) | 5/22 (23) |
| Mechanical ventilation days (censored) | Mean (CI) | 14.4 (18.9 to 10) | 18.2 (25.5 to 10.8) | 11.1 (16.4 to 5.7) |
| Total days of ventilation rescue measures | Mean (CI) | 2.9 (4.3 to 1.4) | 3.6 (5.6 to 1.5) | 2.3 (4.4 to 0.1) |
| Therapeutic anticoagulation used | N (%) | 8 | 4/20 (20) | 4/22 (18) |
| Mean platelet count | Mean (CI) | 239 (269 to 209) | 268 (321 to 216) | 212 (246 to 179) |
| Mean platelet to neutrophil ratio | Mean (CI) | 35.2 (42 to 28.4) | 34.8 (45.2 to 24.3) | 35.6 (45.4 to 28.9) |
See table 1 for details on the variables shown. There were no statistically significant differences between aCL IgG positive and aCL IgG negative patients for all variables, using ANOVA for continuous variables and Fisher’s exact test for categorical variables at α=0.05, followed by the false discovery rate at q=0.05.
aCL, anticardiolipin; ANOVA, analysis of variance; APACHE, Acute Physiology and Chronic Health Evaluation (score); ICU, intensive care unit; SOFA, sequential organ failure assessment (score).