Table 1

ROC analysis findings (AUC) of genetic risk scores in different populations

PredictorsPopulation tested in
EuropeanEast AsianIranianTurkish
HLA-B27 alone0.869 (0.865–0.874)0.901 (0.895–0.906)0.831 (0.807–0.854)0.821 (0.804–0.838)
European non-MHC PRS0.782 (0.776–0.788)*0.594 (0.539–0.560)0.534 (0.500–0.569)0.568 (0.542–0.595)
European overall PRS0.924 (0.920–0.928)*0.788 (0.779–0.796)0.852 (0.826–0.879)0.854 (0.836–0.872)
East Asian non-MHC PRS0.555 (0.547–0.563)0.731 (0.722–0.741)*0.565 (0.531–0.598)0.554 (0.528–0.581)
East Asian overall PRS0.880 (0.875–0.887)0.948 (0.943–0.952)*0.872 (0.848–0.895)0.840 (0.821–0.860)
MRI EUR0.885
MRI CH41 0.62
CRP0.7
  • *10-fold cross-validation. All other PRS AUC values are external validation statistics.

  • AUC, area under the curve; CRP, C-reactive protein; PRS, Polygenic Risk Score; ROC, receiver operator characteristic .