Predictors | Population tested in | |||
European | East Asian | Iranian | Turkish | |
HLA-B27 alone | 0.869 (0.865–0.874) | 0.901 (0.895–0.906) | 0.831 (0.807–0.854) | 0.821 (0.804–0.838) |
European non-MHC PRS | 0.782 (0.776–0.788)* | 0.594 (0.539–0.560) | 0.534 (0.500–0.569) | 0.568 (0.542–0.595) |
European overall PRS | 0.924 (0.920–0.928)* | 0.788 (0.779–0.796) | 0.852 (0.826–0.879) | 0.854 (0.836–0.872) |
East Asian non-MHC PRS | 0.555 (0.547–0.563) | 0.731 (0.722–0.741)* | 0.565 (0.531–0.598) | 0.554 (0.528–0.581) |
East Asian overall PRS | 0.880 (0.875–0.887) | 0.948 (0.943–0.952)* | 0.872 (0.848–0.895) | 0.840 (0.821–0.860) |
MRI EUR | 0.885 | |||
MRI CH41 | 0.62 | |||
CRP | 0.7 |
*10-fold cross-validation. All other PRS AUC values are external validation statistics.
AUC, area under the curve; CRP, C-reactive protein; PRS, Polygenic Risk Score; ROC, receiver operator characteristic .