Table 1

Characteristics of patients in discovery and validation cohorts

VariableDiscovery totalDiscovery cohort 1Discovery cohort 2Discovery cohort 3Discovery cohort 4Validation
No of patients (after QC) 113 (106)12 (11)20 (17)11 (10)70 (68) 60 (60)
Osteoarthritis joint Knee or hip KneeKneeHipKnee Knee
Low-grade OA cartilage samples after QC 87 11161050 60
High-grade OA cartilage samples after QC 95 10161059
Synovium samples after QC 77 1661
Females, n (%) after QC 63 (59)2 (19)12 (71)8 (73)41 (60) 27 (45)
Age, average years (range) after QC 69 (38–88)69 (50–88)70 (54–79)61 (44–88)70 (38–84) 72 (63–85)
  • OA, osteoarthritis; QC, quality control.