Table 1

The MR estimates from each method of the causal effect of gut microbiome on RA risk

MethodNumber of SNPsOR (95% CI)Association
p value
Cochrane Q statisticHeterogeneity
p value
*Number of SNPs*OR (95% CI)*Association
p value
*Cochrane Q statistic*Heterogeneity
p value
MR Egger260.97 (0.95 to 0.99)0.013306.48.78E–51251.00 (0.99 to 1.00)0.28629.81.54E–01
IVW260.98 (0.96 to 0.99)0.002309.76.79E–51250.99 (0.99 to 1.00)0.05730.31.75E–01
Weighted median261.00 (0.98 to 1.00)0.143N/AN/A251.00 (0.99 to 1.00)0.166N/AN/A
  • *Sensitivity analysis without rs1230666.

  • IVW, inverse variance weighted; MR, Mendelian randomisation; N/A, not applicable; RA, rheumatoid arthritis; SNP, single nucleotide polymorphism.