The MR estimates from each method of the causal effect of gut microbiome on RA risk
| Method | Number of SNPs | OR (95% CI) | Association p value | Cochrane Q statistic | Heterogeneity p value | *Number of SNPs | *OR (95% CI) | *Association p value | *Cochrane Q statistic | *Heterogeneity p value |
| MR Egger | 26 | 0.97 (0.95 to 0.99) | 0.013 | 306.4 | 8.78E–51 | 25 | 1.00 (0.99 to 1.00) | 0.286 | 29.8 | 1.54E–01 |
| IVW | 26 | 0.98 (0.96 to 0.99) | 0.002 | 309.7 | 6.79E–51 | 25 | 0.99 (0.99 to 1.00) | 0.057 | 30.3 | 1.75E–01 |
| Weighted median | 26 | 1.00 (0.98 to 1.00) | 0.143 | N/A | N/A | 25 | 1.00 (0.99 to 1.00) | 0.166 | N/A | N/A |
*Sensitivity analysis without rs1230666.
IVW, inverse variance weighted; MR, Mendelian randomisation; N/A, not applicable; RA, rheumatoid arthritis; SNP, single nucleotide polymorphism.