UPCR
| Control (n=100) | Voclosporin (n=116) | Treatment Comparison of Voclosporin to Control | ||||
| n | UPCR (mg/mg) | n | UPCR (mg/mg) | UPCR (mg/mg) | p-value | |
| Pre-treatment baseline, mean | 100 | 3.87 | 116 | 3.94 | NC | NC |
| Change from pre-treatment baseline, LS mean | ||||||
| Year 1 | 100 | -2.4 | 116 | -3.0 | -0.6 | 0.0080 |
| Year 2 | 51 | -2.1 | 73 | -3.1 | -1.0 | 0.0004 |
LS, least squares; NC, not calculated; UPCR, urine protein creatinine ratio.
Mixed effects model for repeated measures (MMRM) analysis of LS mean change from pre-treatment baseline for UPCR included terms for baseline covariate, treatment, visit and treatment by visit interaction. Integrated results include data from pre-treatment baseline of AURORA 1, the one-year treatment period in AURORA 1 and up to a one-year treatment period in AURORA 2.