Table 1.

Summary of adverse events (AEs) through Week 16

Patients, n (%)Deucravacitinib
n=332
Placebo
n=165
Apremilast
n=168
Any AEs176 (53.0)70 (42.4)93 (55.4)
Severe AEs5 (1.5)7 (4.2)5 (3.0)
Serious AEs7 (2.1)9 (5.5)4 (2.4)
AEs leading to treatment discontinuation6 (1.8)7 (4.2)10 (6.0)
Most common AEs (≥5% in any arm)
 Nasopharyngitis21 (6.3)7 (4.2)14 (8.3)
 Upper respiratory tract infection21 (6.3)6 (3.6)3 (1.8)
 Headache16 (4.8)5 (3.0)17 (10.1)
 Diarrhea13 (3.9)6 (3.6)17 (10.1)
 Nausea7 (2.1)4 (2.4)19 (11.3)