Table 1.

Adjusted odds ratios (ORs)1 for PTB and SGA in RA-pregnancies in relation to disease activity and functional status during pregnancy vs. control pregnancies

Preterm birthSmall for gestational age1
Pregnancies, nEvents,
n (%)
Adjusted OR
(95% CI)
Pregnancies, nEvents,
n (%)
Adjusted OR
(95% CI)
Control-pregnancies217312794 (5)1 (REF)17184418 (2)1(REF)
All RA pregnancies21734144 (8)1.92 (1.56-2.35)172275 (4)1.93 (1.45-2.57)
DAS28-CRP3,4<3.245926 (6)1.05 (0.64-1.72)45613 (3)0.96 (0.49-1.91)
3.2-5.118217 (9)2.40 (1.40-4.11)18113 (7)3.13 (1.64-5.97)
>5.1435 (12)2.77 (0.86-8.87)434 (9)4.59 (1.59-13.2)
No information105096 (9)2.18 (1.71-2.78)104245 (4)2.06 (1.46-2.90)
HAQ-score3<0.533819 (6)1.31 (0.79-2.16)3358 (2)0.93 (0.41-2.12)
0.5-0.916615 (9)2.37 (1.34-4.19)1655 (3)1.50 (0.60-3.74)
≥119619 (10)1.85 (1.06-3.24)19518 (9)3.70 (2.05-6.67)
No information103491 (9)2.06 (1.60-2.64)102744 (4)1.98 (1.39-2.82)
CRP, mg/L3<1045521 (5)0.91 (0.55-1.51)45214 (3)1.09 (0.57-2.07)
10-2919122 (11)2.58 (1.52-4.38)19012 (6)2.68 (1.38-5.22)
≥30579 (16)4.59 (2.28-9.22)575 (9)4.12 (1.68-10.1)
No information103192 (9)2.10 (1.64-2.70)102344 (4)2.05 (1.44-2.90)
  • 1Missingness on small for gestational age in 12 RA-pregnancies and 128 control-pregnancies 2Only among live births, i.e. stillbirths excluded. 3Maximum value any time during pregnancy 4Defined as DAS28-CRP without patient’s global health VAS