Table 1.

Relative Risk of Gout by Body Mass Index, Stratified by Mean Genetic Score

HPFS (men)
Below MeanAbove Mean
BMIOverall<2525-30>30Overall<2525-30>30
No. Cases3338817273650172349129
Person-Years10405543314492531148898634419944609610544
Age-Adjusted RR-1.0 (ref)1.71 (1.32, 2.22)3.00 (2.18, 4.12)-1.0 (ref)1.80 (1.50, 2.16)2.87 (2.27, 3.62)
MV Adjusted* RR-1.0 (ref)1.53 (1.18, 1.99)2.31 (1.66, 2.21)-1.0 (ref)1.63 (1.35, 1.96)2.38 (1.87, 3.03)
NHS (women)
Below MeanAbove Mean
BMIOverall<2525-30>30Overall<2525-30>30
No. Cases17347408635772120165
Person-Years24439212384976414441292392591202297612342907
Age-Adjusted RR-1.0 (ref)1.23 (0.81, 1.88)4.46 (3.10, 6.41)-1.0 (ref)2.41 (1.79, 3.23)5.68 (4.82, 7.52)
MV Adjusted* RR-1.0 (ref)1.00 (0.65, 1.53)2.84 (1.92, 4.20)-1.0 (ref)1.97 (1.46, 2.65)3.61 (2.68, 4.87)
  • *Adjusted for age (continuous), menopause, use of hormone therapy (never, past or current), history of hypertension, and systolic and diastolic blood pressure, alcohol, total energy intake and intake of meat, seafood and dairy foods (all continuous).