The association between the change of the mSASSS over two years and current and/or previous treatment with TNFi in the longitudinal generalized estimation equation analysis.
| TNFi treatment definition | |||
| Reference | β* (95% CI) | TNFi for ≥12 months in the previous 2-year interval | TNFi for ≥12 months in the current 2-year interval |
| Yes | No TNFi for ≥12 months in the current 2-year interval | -0.19 (-0.56 to 0.18) | |
| Yes | No TNFi for ≥12 months in the previous 2-year interval | -0.56 (-0.95 to -0.17) | |
| Yes | Yes | No TNFi for ≥12 months in the current and previous 2-year intervals | -0.59 (-1.03 to -0.15) |
*Parameter estimates from the multivariable models adjusted for sex, symptom duration at the beginning of the current 2-year interval, time-averaged ASDAS in the current 2-year interval, smoking in the current 2-year interval, classification as non-radiographic or radiographic axSpA, and mSASSS at the beginning of the current 2-year interval.