Table 1.

Comparison between inflammatory arthritis pregnancies treated with low-dose aspirin and those untreated.

LDA (n 19)Not LDA (n 39)p
Maternal age at conception, median (IQR)33 (30.5 - 36.5)33 (28.2 - 35)
BMI, median (IQR)25.4 (22.9 - 28.5)22.5 (20.4 - 24.5)
Smoking, n (%)3 (15.8%)4/36 (11.1%)0.68
Previous APO, n (%)7/11 (63.7%)7/13 (56.1%)0.34
aPL+, n (%)3 (15.8%)1/36 (2.8%)0.1
CRP+, n (%)5/15 (33.3%)11/27 (40.7%)0.75
GC at baseline, n (%)9 (47.4%)15/34 (44.1%)0.82
cDMARDs at baseline, n (%)1 (5.3%)3/34 (8.8%)1
bDMARDs at baseline, n (%)6 (31.6%)11 (28.2%)0.79
Live-birth pregnancy, n (%)18 (94.7%)32 (82.1%)0.25
Pregnancy loss, n (%)1 (5.3%)7 (17,9%)0.25
Hypertensive disorders, n (%)2/18 (11.1%)6/38 (15,8%)1
HELLP syndrome, n (%)0 (0%)0 (0%)1
PROM, n (%)0 (0%)3/38 (7.9%)0.54
Preterm delivery, 34-37 GW, n (%)2 (10.5%)2 (5.2%)0.59
Preterm delivery, <34 GW, n (%)1 (5.3%)1 (2.6%)1
IUGR, n (%)0 (0%)3 (7.8%)0.54
SGA, n (%)0 (0%)0 (0%)1
Pregnancy/Peripartum complications, n (%)3 (15.8%)11 (28.9%)0.35
  • Legend: aPL, Antiphospholipid syndrome; bDMARDs, biological disease-modifying antirheumatic drugs; BMI, Body mass index; cDMARDs, Conventional disease-modifying antirheumatic drugs; CRP, C-reactive protein; GC, Glucocorticoids; GW, gestational week; HELLP, haemolysis, elevated liver enzymes, and low platelets; Hypertensive disorder defined as gestational hypertension, preeclampsia and eclampsia; IQR, Interquartile range; IUGR, intrauterine growth restriction; LDA, Low-dose Aspirin; Pregnancy loss defined as early fetal-loss, miscarriage and still-birth; PROM, Premature rupture of membranes; SGA, Small for gestational age.