Table 1

Sample characteristics stratified by case/control status for discovery and replication cohorts

CasesControlsP value
Discovery cohort (UK Biobank)
Female4470 (64.7%)128 599 (47.1%)<0.0001
Male2444 (35.3%)114 330 (52.9%)
Age (mean±SD)57.8±7.4557.0±8.09<0.0001
BMI (mean±SD)30.02±5.9726.83±4.40<0.0001
Replication cohorts
TwinsUK
Female1041 (93.7%)3116 (87.6%)<0.0001
Male70 (6.3%)440 (12.4%)
Age (mean±SD)54.78±10.4850.12±13.21<0.0001
BMI (mean±SD)27.39±5.1125.74±4.57<0.0001
HUNT
Female63155836<0.0001
Male42417403
Age (mean±SD)55.95±9.4854.82±10.31<0.0001
BMI (mean±SD)27.37±4.3326.52±3.88<0.0001
ELSA
Female1090 (64.9%)2660 (50.2%)<0.001
Male589 (35.1%)2644 (49.8%)
Age (mean±SD)68.10±9.4966.55±9.98<0.0001
BMI (mean±SD)28.60±4.9827.08±4.22<0.0001
RS-1
Female4221323<0.0001
Male1101281
Age (mean±SD)64.49±5.3064.60±5.240.6660
BMI (mean±SD)26.98±3.9126.14±3.54<0.0001
RS-2
Female106745<0.0001
Male38676
Age (mean±SD)61.59±4.5961.93±4.720.2651
BMI (mean±SD)28.54±4.7327.77±3.910.0363
RS-3
Female1281516<0.0001
Male271263
Age (mean±SD)56.28±5.7756.32±5.460.0348
BMI (mean±SD)28.54±4.86)27.71±4.620.0827
  • BMI, body mass index; ELSA, The English Longitudinal Study of Ageing; HUNT, The Nord-Trøndelag Health Survey; RS-1, RS-2 and RS-3, The Rotterdam Study 1, 2 and 3; SD, Standard deviation .