Table 2

Liability-scale RA heritability h 2 estimated from the tested genome-wide variants in each ancestry

AncestryAll tested variantsNon-MHC variants*
h 2 SE of h 2 h 2 SE of h 2 Proportion of h2 explained by
Known RA lociNovel RA loci
East Asian0.1760.0530. 1230. 01243.0%6.9%
European0. 2750.0960. 1850. 02138.1%1.8%
  • *The MHC region was defined as spanning as the 24–37 Mb region of chromosome 6 in hg19.

  • MHC, major histocompatibility complex; RA, rheumatoid arthritis.