Table 1

Independent association results from the global analysis comparing scleroderma and controls after the sequential conditional analysis

GeneVariationBPNOR (95% CI)P valueConditioned P value
HLA-DQA1rs1048372T*32 642 659140.70 (0.67 to 0.73)1.29E-63
HLA-DRB5/HLA-DQA1rs482044G32 608 287140.73 (0.70 to 0.76)7.09E-501.10E-35
HLA-DPB1rs1126511T*33 080 689141.21 (1.16 to 1.27)2.01E-162.37E-25
COL11A2rs9469378C33 191 887141.44 (1.31 to 1.58)8.02E-142.16E-14
HLA-DQA1rs1142338T*32 641 545141.86 (1.67 to 2.07)3.12E-293.16E-12
HLA-B/MICArs2844532G2 685 662140.77 (0.73 to 0.81)2.11E-231.54E-11
HLA-DQA2rs17500468G32 743 401141.36 (1.28 to 1.43)1.10E-273.64E-10
MICA/MICBrs3094228G31 462 150141.29 (1.23 to 1.36)1.30E-265.42E-09
BTNL2/HLA-DRArs9268515C32 411 518141.08 (1.03 to 1.14)3.01E-031.76E-09
HLA-DRB1DRB1*11:0432 584 287132.11 (1.92 to 2.31)2.52E-56
HLA-DQB1DQB1*02:0232 663 284140.56 (0.51 to 0.60)5.79E-513.84E-45
HLA-DPB1DPB1*13:0133 081 591142.05 (1.82 to 2.31)6.10E-329.77E-30
HLA-DQA1DQA1*04:0132 640 529141.86 (1.67 to 2.07)3.12E-292.97E-28
HLA-DRB1DRB1*13:0132 584 287140.68 (0.62 to 0.75)2.15E-163.00E-14
HLA-BB*08:0131 355 516141.22 (1.15 to 1.30)1.29E-101.79E-12
HLA-DQB1DQB1*05:0132 663 284141.20 (1.14 to 1.27)3.25E-101.33E-12
HLA-DPB1DPB1*03:0133 081 591141.19 (1.12 to 1.27)3.15E-084.81E-08
HLA-DPB1DPB1*06:0133 081 591131.47 (1.27 to 1.70)2.19E-072.15E-08
HLA-DRB1AA Ile6732 584 192140.70 (0.67 to 0.73)1.70E-63
HLA-DPB1AA Ile7633 080 885141.74 (1.56 to 1.93)1.73E-233.70E-29
HLA-DRB1AA Tyr6032 584 213140.65 (0.62 to 0.69)3.50E-527.03E-22
HLA-DQA1AA Thr6932 641 502141.85 (1.66 to 2.05)1.65E-301.90E-19
HLA-DRB1AA Ala5832 584 219141.46 (1.37 to 1.55)2.88E-332.56E-14
HLA-DPB1AA Leu1133 080 690141.21 (1.16 to 1.27)2.01E-161.65E-11
  • BP position based on build hg38.

  • Sequential conditional association analyses were performed separately for each variant type.

  • *Coding single-nucleotide polymorphisms: rs1126511 (SNP_DPB1_33156444), rs1142338 (SNP_DQA1_32717300) and rs1048372 (SNP_DQA1_32718414).

  • BP, base pair; N, number of cohorts where the variant was meta-analysed.