Table 3

Summary of the independent association results from the stratified analysis

GeneAllelesOR*P value*Conditioned P valuePhenotypeOR†Intracase P value†
HLA-DQA1DQA1*02:010.545.23E-51NA‡lcSSc0.712.08E-08
HLA-DQA1DQA1*05:011.491.16E-301.59E-11dcSSc1.301.76E-11
HLA-DRB1DRB1*08:013.189.73E-574.00E-64ACA2.171.42E-10
HLA-DRB1DRB1*07:010.361.17E-631.84E-45ACA0.423.85E-27
HLA-DPA1DPA1*02:011.877.91E-432.93E-19ATA2.411.09E-40
HLA-DQB1DQB1*03:011.867.11E-477.00E-19ATA1.671.73E-22
  • *Association effect and p value compared with the control group.

  • †Association effect and p value in the intracase comparisons (dcSSc with lcSSc and ATA with ACA).

  • ‡Not available as it was the most significant allele in the sequential conditional model.

  • ACA, anticentromere; ATA, antitopoisomerase; dcSSc, diffuse cutaneous systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis.