Table 2

Colocalisation analysis for the independently associated SNPs

SNPAssociation P valueeGENETissueGTEx P value
rs4820441.10E-35TNXAOesophagus (mucosa)8.46E-05
STK19PKidney cortex7.10E-07
HLA-DRB1Adipose (visceral)1.70E-18
Brain3.50E-16
Cardiac ventricle1.20E-22
Liver1.50E-06
HLA-DRB6Brain3.92E-21
BRD2Nerve (tibial)1.05E-04
rs1126511 (SNP_DPB1_33156444)2.37E-25HLA-DPA2Brain4.46E-07
LEMD2Colon transverse1.04E-04
rs94693781.16E-14RING1Adipose (subcutaneous)2.70E-05
Cultured fibroblasts2.20E-06
Oesophagus (muscularis)1.30E-05
Skin5.50E-06
ITPR3Oesophagus (mucosa)7.87E-06
rs1142338 (SNP_DQA1_32717300)*3.16E-12C2Transformed lymphocytes6.03E-08
rs30942285.42E-09DDR1Oesophagus (muscularis)3.85E-05
  • eGENE is the gene modulated by SNP.

  • *Colocalisation was found for the proxy of rs1142338 (SNP_DQA1_32717300), the rs4713586 (r2=0.95).

  • GTEx, Genotype-Tissue Expression; SNP, single-nucleotide polymorphism.