Table 4

Multivariable analyses for disease severity

VariableImputed analysis* (n=694)Available case analysis (n=601)
n/NOR (95% CI)P valuen/NOR (95% CI)P value
Age (years)87/6941.08 (1.05–1.10)<0.00173/6011.08 (1.05–1.10)<0.001
Female gender44/4620.45 (0.25–0.80)0.00737/3950.43 (0.24–0.78)0.005
BMI87/6941.07 (1.02–1.12)0.00673/6011.07 (1.02–1.12)0.007
Hypertension51/1821.86 (1.01–3.42)0.04742/1621.83 (0.99–3.37)0.054
Corticosteroids51/2161.97 (1.09–3.54)0.02445/1882.04 (1.13–3.67)0.018
Mycophenolate mofetil/mycophenolic acid3/166.60 (1.47–29.62)0.0143/146.51 (1.45–29.23)0.015
Rituximab11/344.21 (1.61–10.98)0.00310/324.60 (1.75–12.11)0.002
  • ORs were calculated using multivariable penalised logistic regression models (Firth method), using a forward selection method, with patients with mild or moderate infection as reference. Only variables selected by the model are presented. Full model included age, sex, interstitial lung disease, diabetes, BMI, hypertension, chronic renal failure, disease history, corticosteroids, mycophenolate mofetil/mycophenolic acid and rituximab.

  • n/N indicated the number of events/number of cases.

  • *ORs and p value were calculated after multiple imputations (m=10) to handle missing data.

  • BMI, body mass index.