Table 4

Multivariable analyses for disease severity

Variable	Imputed analysis* (n=694)			Available case analysis (n=601)
Variable	n/N	OR (95% CI)	P value	n/N	OR (95% CI)	P value
Age (years)	87/694	1.08 (1.05–1.10)	<0.001	73/601	1.08 (1.05–1.10)	<0.001
Female gender	44/462	0.45 (0.25–0.80)	0.007	37/395	0.43 (0.24–0.78)	0.005
BMI	87/694	1.07 (1.02–1.12)	0.006	73/601	1.07 (1.02–1.12)	0.007
Hypertension	51/182	1.86 (1.01–3.42)	0.047	42/162	1.83 (0.99–3.37)	0.054
Corticosteroids	51/216	1.97 (1.09–3.54)	0.024	45/188	2.04 (1.13–3.67)	0.018
Mycophenolate mofetil/mycophenolic acid	3/16	6.60 (1.47–29.62)	0.014	3/14	6.51 (1.45–29.23)	0.015
Rituximab	11/34	4.21 (1.61–10.98)	0.003	10/32	4.60 (1.75–12.11)	0.002

ORs were calculated using multivariable penalised logistic regression models (Firth method), using a forward selection method, with patients with mild or moderate infection as reference. Only variables selected by the model are presented. Full model included age, sex, interstitial lung disease, diabetes, BMI, hypertension, chronic renal failure, disease history, corticosteroids, mycophenolate mofetil/mycophenolic acid and rituximab.
n/N indicated the number of events/number of cases.
*ORs and p value were calculated after multiple imputations (m=10) to handle missing data.
BMI, body mass index.