Table 2

Genes differentially expressed between responders and non-responders to TNFi

Gene IDLog fold-change (R/NR)P value (R/NR)Adjusted P value (R/NR)
PLAUR_LPS0.48162.86E−060.0023
ITGB1_LPS0.28605.29E−060.0023
CD14_LPS0.57041.78E−050.0041
CCL20_LPS0.62642.04E−050.0041
IL1R1_LPS0.78032.48E−050.0041
IRAK1_LPS0.29643.41E−050.0041
IRAK3_LPS0.39773.49E−050.0041
CLEC5A_LPS0.71803.8E−050.0041
ITGA5_LPS0.26840.00010.0066
LTB4R_LPS0.59850.00010.0069
LTA_LPS−0.33660.00010.0074
BST1_LPS0.51860.00010.0077
IL1RAP_LPS0.47070.00010.0083
CD58_LPS0.26900.00010.0083
CEBPB_LPS0.29890.00010.0083
IL8_LPS0.56940.00020.0083
IFNGR1_LPS0.30220.00020.0097
IL1R2_LPS0.44110.00030.0121
CXCL9_LPS−2.02060.00030.0121
TNFRSF1B_LPS0.31570.00030.0121
IL6R_LPS0.33600.00030.0121
NLRP3_LPS0.38960.00030.0121
CTNNB1_LPS0.14950.00030.0121
FCGRT_LPS0.31590.00030.0121
ITGAX_LPS0.36000.00030.0121
IFNG_LPS−1.43980.00050.0180
CXCL1_LPS0.45150.00060.0180
FCGR2A_LPS0.26340.00060.0180
ITGA6_SEB−0.25690.00060.0180
PRKCD_LPS0.33300.00060.0187
ZEB1_LPS0.34870.00070.0201
CLEC7A_LPS0.37950.00070.0201
PECAM1_LPS0.40500.00080.0218
IRAK1_SEB0.19880.00090.0231
APP_LPS0.19380.00100.0237
FCER1G_LPS0.29020.00110.0255
ICAM5_SEB0.53630.00110.0257
IL8_SEB0.38800.00110.0257
PLAUR_SEB0.30670.00120.0270
IL7R_SEB−0.19910.00120.0270
IGF2R_LPS0.23100.00130.0270
IKZF3_LPS−0.15440.00130.0276
TNFRSF8_LPS0.36470.00140.0276
NFIL3_LPS0.28300.00150.0290
LIF_LPS1.02290.00150.0292
MBP_LPS0.21140.00160.0296
TP53_LPS−0.18460.00160.0296
CXCL2_LPS0.49140.00200.0371
CXCR4_LPS0.28330.00220.0398
ATG7_LPS0.24860.00240.0412
CRADD_SEB0.32380.00250.0435
PLAU_LPS0.47590.00270.0452
SPP1_SEB0.44510.00280.0452
SKI_LPS0.17600.00280.0452
CXCR1_LPS0.67860.00290.0452
TLR2_LPS0.27180.00310.0471
MAP4K4_LPS0.25040.00310.0471
DUSP4_LPS0.45700.00310.0471