Potential regulators of osteoarthritis (OA) severity
| Gene name | No of human studies differentially expressed | No. interactions with OA genes | Rank |
| ACKR2 | 4 | 4 | 241 |
| SAT2 | 3 | 5 | 263 |
| NOG | 4 | 4 | 311 |
| FBLN2 | 4 | 4 | 356 |
| FZD9 | 5 | 4 | 361 |
| MMP14 | 4 | 4 | 362 |
| WIF1 | 3 | 5 | 363 |
| FZD8 | 6 | 6 | 381 |
| ITGA11 | 6 | 4 | 387 |
| CD36 | 3 | 11 | 395 |
The top predicted regulators using network-based expansion of the OA genes are shown. Regulators were filtered to be differentially expressed in at least three human OA expression datasets, to have at least four interactions with known OA genes and to exclude known OA genes. The rank of the network-based score is shown out of 17 557 total genes in the network.