Clinical characteristics of the three patients with systemic sclerosis and COVID-19
| Patient 1 | Patient 2 | Patient 3 | |
| Age (years) | 71 | 84 | 44 |
| Gender | Male | Female | Female |
| Body mass index (kg/m2) | 24.5 | 20 | 29 |
| Disease duration (years) | 4 | 18 | 2 |
| Cutaneous subset | Diffuse | Limited | Limited |
| Autoantibody profile | Anti-RNA polymerase 3 | No specific autoantibody | Anti-RNA polymerase 3 |
| Interstitial lung disease | No | No | No |
| Pulmonary hypertension | No | No | No |
| Other comorbidities | High blood pressure | Chronic renal insufficiency | Thyroidectomy for goitre |
| Dyslipidaemia | Pulmonary embolism | ||
| Rituximab | |||
| Date of the first infusion | 07/17 | 01/15 | 01/18 |
| Dose | 500 mg/6 months | 500 mg/8 months | 1 g/8 months |
| Last infusion | 01/20 | 06/19 | 10/19 |
| B-cell depletion | Complete (February 2020) | Complete (February 2020) | Complete (January 2020) |
| Gammaglobulin (g/L) | 7.0 (February 2020) | 12.9 (February 2020) | 9.5 (January 2020) |
| Associated treatments | |||
| csDMARDs | Methotrexate (20 mg/week) | None | Methotrexate (15 mg/week) |
| Prednisone (mg/day) | 5 | 5 | 2.5 |
| COVID-19 | |||
| Day 0 | 01/04/20 | 12/04/20 | 15/03/20 |
| Confirmation by RT-PCR | Not done | Yes | Yes |
| Compatible chest CT scan | Yes | Yes | Yes |
| First symptoms | Fever, cough, dyspnoea | Fever, diarrhoea, cough | Fever, cough, sore throat, myalgia |
| Day of clinical worsening | Day 19 | Day 15 | Day 23 |
| Hospitalisation | Yes | Yes | Yes |
| Hospitalisation in ICU | Yes | No | Yes |
| Duration in hospitalisation/ICU | 7 days | Still in the general ward | Still in the general ward |
| Ventilatory support | NIV | HFNC | CPAP |
| Antibiotics | Yes | Yes | Yes |
| Other specific treatment | No | Yes (anakinra, corticosteroids, tocilizumab) | No |
| Outcome | Favourable | Favourable | Favourable |
CPAP, continuous positive airway pressure; csDMARD, conventional synthetic disease-modifying anti-rheumatic drug; HFNC, high-flow nasal cannula; ICU, intensive care unit; NIV, non-invasive ventilation; RT-PCR, reverse transcription PCR.