rsID | EA | EAF | Thumb OA (7280 cases; 605 132 controls) | Finger OA (7037 cases; 222 772 controls) | Hand OA (8591 cases; 224 326 controls) | Hip OA (17 151 cases, 613 790) | Knee OA (24 919 cases, 613 702 controls | ||||||||||
OR | 95% CI | P value | OR | 95% CI | P value | OR | 95% CI | P value | OR | 95% CI | P value | OR | 95% CI | P value | |||
rs10916199 | A | 0.81 | 0.91 | 0.86 to 0.95 | 5.7×10−5 | 0.98 | 0.93 to 1.04 | 0.57 | 1.03 | 0.98 to 1.08 | 0.32 | 1.00 | 0.98 to 1.03 | 0.95 | 0.99 | 0.97 to 1.02 | 0.59 |
rs2070852 | C | 0.69 | 0.97 | 0.89 to 1.05 | 0.47 | 0.99 | 0.94 to 103 | 0.58 | 0.99 | 0.96 to 103 | 0.80 | 0.98 | 0.96 to 1.01 | 0.22 | 0.99 | 0.97 to 1.01 | 0.40 |
rs4764133 | T | 0.39 | 1.07 | 1.03 to 1.12 | 6.3×10−4 | 1.12 | 1.07 to 1.17 | 5.7×10−7 | 1.09 | 1.04 to 1.13 | 6.7×10−4 | 0.99 | 0.96 to 1.01 | 0.30 | 0.98 | 0.96 to 1.00 | 0.018 |
rs12049916 | A | 0.77 | 1.00 | 0.96 to 1.05 | 0.87 | 0.99 | 0.94 to 1.04 | 0.67 | 0.99 | 0.94 to 1.04 | 0.68 | 0.96 | 0.93 to 0.99 | 2.9×10−3 | 0.99 | 0.97 to 1.01 | 0.27 |
Thumb OA, finger OA, hand OA GWAS summary statistics are from the deCODE cohort. Hip OA and knee OA summary statistics are from a meta-analysis of deCODE and UK Biobank cohorts.
EA, effect allele; EAF, effect allele frequency; NEA, non-effect allele; OA, osteoarthritis.