Table 1

Demographic, clinical and electrocardiographic parameters in patients with RA receiving low-dose hydroxychloroquine or other DMARDs

RA treated with hydroxychloroquine (n=104)RA treated with other DMARDs (n=541)P value
Age (years)61.0±9.260.6±9.50.715
Disease duration (months)114±103129±1160.210
CRP (mg/dL)1.08±2.42.02±6.10.009
ESR (mm/hour)26.2±2027.5±220.599
HR (beats/min)70.1±8.169.2±9.90.438
QTc (ms)420.3±30.8410.6±28.70.002
QTc, prolonged, n (%)10 (9.6)24 (4.4)0.030
QTc, >500 ms, n(%)*02 (0.4)1
K+† (mEq/L)4.1±0.34.1±0.30.862
Ca++† (mg/dL)9.2±0.49.1±0.40.752
  • *Fisher’s exact test.

  • †Available in 150 subjects. Values are mean ±1 SD.

  • CRP, C reactive protein; DAS28-ESR, Disease Activity Score 28-joints measured with erythrocyte sedimentation rate; DMARD, disease-modifying antirheumatic drug; HAQ, Health Assessment Questionnaire; HR, heart rate; QTc, QT in lead II corrected with Bazett’s formula; RA, rheumatoid arthritis.