Cumulative incidence and risk ratio of VTE during 1-year follow-up after rheumatologist visit in Swedish patients with RA versus matched general population referents (1:5), and in DAS28 categories
| No of VTE events (cumulative incidence, %) | ||||||
| Within RA, between DAS28 categories | Entire RA pop* | Gen pop | ||||
| Remission | Low | Intermediate | High | |||
| Type | ||||||
| Any | 496 (0.52) | 271 (0.63) | 743 (0.80) | 350 (1.08) | 2241 (0.71) | 5301 (0.36) |
| DVT | 346 (0.36) | 170 (0.40) | 467 (0.50) | 196 (0.61) | 1408 (0.45) | 3303 (0.22) |
| PE | 150 (0.16) | 101 (0.24) | 276 (0.30) | 154 (0.48) | 833 (0.26) | 1998 (0.14) |
| Sex | ||||||
| Male | 188 (0.60) | 71 (0.66) | 190 (0.94) | 78 (1.10) | 664 (0.80) | 1631 (0.43) |
| Female | 308 (0.47) | 200 (0.62) | 553 (0.76) | 272 (1.08) | 1577 (0.68) | 3670 (0.34) |
| Age | ||||||
| 18–49 | 37 (0.16) | 23 (0.30) | 54 (0.31) | 24 (0.39) | 174 (0.27) | 419 (0.13) |
| 50–74 | 332 (0.54) | 174 (0.62) | 450 (0.74) | 215 (1.01) | 1386 (0.68) | 3541 (0.37) |
| 75- | 127 (1.06) | 74 (1.03) | 239 (1.65) | 111 (2.27) | 681 (1.44) | 1341 (0.71) |
| Risk ratios (95% CI)† | ||||||
| Within RA, between DAS28 categories | ||||||
| Remission | Low | Intermediate | High | |||
| Unadjusted | 1 (ref) | 1.22 (1.05 to 1.43) | 1.56 (1.37 to 1.76) | 2.10 (1.79 to 2.46) | ||
| Adjusted | 1 (ref) | 1.12 (0.96 to 1.31) | 1.48 (1.30 to 1.68) | 2.03 (1.73 to 2.38) | ||
| RA population (including DAS28 categories) versus general population | ||||||
| Remission | Low | Intermediate | High | Entire RA pop | Gen pop | |
| Unadjusted | 1.43 (1.28 to 1.59) | 1.75 (1.52 to 2.01) | 2.23 (2.02 to 2.45) | 3.00 (2.62 to 3.43) | 1.96 (1.83 to 2.11) | 1 (ref) |
| Adjusted | 1.34 (1.13 to 1.58) | 1.51 (1.25 to 1.82) | 1.99 (1.72 to 2.31) | 2.74 (2.31 to 3.25) | 1.88 (1.65 to 2.15) | 1 (ref) |
Patients and referents followed from first visit registered after 2006 until 2018.
*Includes VTE events following a visit with missing DAS28 value (n=381, 17% of all VTE events).
†Risk ratios adjusted for age, sex and calendar year.
DAS28, Disease Activity Score 28; DVT, deep vein thrombosis; PE, pulmonary embolism; RA, rheumatoid arthritis; VTE, venous thromboembolism.