Gene-set analyses of SLE-associated genes and involved pathways
| Set name | Genes tested | No of SNVs all/common/rare | FDRALL | FDRCOMMON | FDRRARE |
| Interferon (ref 21) | 33 | 4204/849/2866 | 0.0018 | 0.66 | 0.65 |
| Interferonopathy (ref 22,23) | 11 | 2034/463/1271 | 0.0028 | 4.1E-07 | 0.24 |
| SLE GWAS (ref 3,4) | 88 | 18790/5326/11465 | 1.5E-12 | 2.0E-15 | 0.18 |
| Complement* | 32 | 4712/1094/3086 | 0.00071 | 2.8E-07 | 0.20 |
| Monogenic SLE (ref 24) | 24 | 3745/930/2371 | 2.9E-07 | 2.9E-11 | 0.020 |
All: including all MAFs; Common: MAF >0.05; Rare: MAF <0.01.
*The complement part of KEGG pathway hsa04610.
FDR, false discovery rate; GWAS, genome-wide association study; KEGG, kyoto encyclopedia of genes and genomes; MAF, minor allele frequency; SLE, systemic lupus erythematosus; SNV, single-nucleotide variant.