Table 1

The main clinical, laboratory and immunological findings are presented

Patient NoSex/ageMedical historyAnti-SARS-CoV-2 IgGCOVID-19-related symptomsSOFA scorePulmonary imagingOutcomeElevated muscle enzymesProlonged
aPPT
Autoantibodies
1M/78NonePOSDyspnoea10Diffuse infiltrates and ground glassDeathYesYesa-CL (IgG)
2M/59Sleep apnoeaPOSFever, cough, dyspnoea3Diffuse infiltrates and ground glassAliveNoNoa-CL (IgG+IgM)
3M/70HypertensionPOSFever, dry cough, dyspnoea10Diffuse infiltrates and ground glassAliveNoNoNEG
4M/46DyslipidaemiaPOSFever8Diffuse infiltrates and ground glassAliveNoNoNEG
5M/62NonePOSFever, cough, dyspnoea8Diffuse infiltrates and ground glassAliveNoNoNEG
6M/54SmokingPOSFever4Diffuse infiltratesAliveYesYesANA 1/320 fine speckled cytoplasmic
7M/79NonePOSFever, cough, dyspnoea9Diffuse infiltrates and ground glassAliveNoNoNEG
8M/70NonePOSFever, productive cough11Diffuse infiltrates and ground glassAliveNoYesNEG
9M/71NonePOSFever, cough, dyspnoea9Diffuse infiltrates and ground glassAliveYesYesp-ANCA 1/20
10M/61Coronary artery diseasePOSFever, cough, dyspnoea3Diffuse infiltrates and ground glassAliveNoNoANA 1/320 speckled cytoplasmic, p-ANCA 1/20
a-CL (IgG+IgM)
11M/64Hyperthyroid, dyslipidaemiaPOSFever, cough, dyspnoea11Diffuse infiltratesAliveYesYesc-ANCA 1/640
12M/61Hypertension, diabetes mellitusNEGFever, cough10Diffuse infiltratesAliveNoNoNEG
13M/62Smoking, arrhythmiaPOSFever, cough, dyspnoea, diarrhoea7Diffuse infiltrates and ground glassAliveYesYesa-CL (IgG+IgM), a-CCP 70 IU
14F/65NonePOSFever, cough, dyspnoea8Diffuse infiltratesAliveNoNoANA 1/160 fine speckled nucleolar
15F/58Asthma, dyslipidaemia, hypertension, psoriasis, hepatitisPOSFever, productive cough, dyspnoea11Diffuse infiltratesDeathYesNoa-CL (IgG)
16F/85Dyslipidaemia, hypertensionPOSFever, cough8Diffuse infiltratesIn ICUNoNoANA 1/160 fine speckled nucleolar, a-β2GPI (IgG+IgM)
17M/75Hypertension, G6PD (−), hypothyroidism, renal CAPOSFever, cough, dyspnoea9Diffuse infiltrates and ground glassIn ICUYesNoANA 1/320 fine speckled nucleolar, Ro60, a-β2GPI (IgG)
18F/60DyslipidaemiaPOSFever9Diffuse infiltrates and ground glassAliveYesYesNEG
19F/53ObesityPOSFever, myalgia10Diffuse infiltratesAliveYesYesNEG
20M/61Hypertension, dyslipidaemiaPOSFever, cough, dyspnoea6Diffuse infiltrates and ground glassIn ICUYesNoANA 1/320 fine speckled nucleolar, a-β2GPI (IgG)
21F/56Hypertension, obesityPOSFever, cough, dyspnoea9Diffuse infiltrates and ground glassIn ICUYesYesa-CL (IgG)
22M/67Diabetes, hypertension,
dyslipidaemia
POSHeadache, cough, fever, fatigue5Diffuse infiltrates and ground glassAliveNoYesc-ANCA 1/20, a-β2GPI (IgM)
23F/66ObesityPOSFever, cough9Diffuse infiltrates and ground glassAliveYesNoANA 1/160 fine speckled nucleolar, a-β2GPI (IgM)
24M/43NonePOSFever, cough8Diffuse infiltrates and ground glassAliveNoNoANA 1/320 fine speckled nucleolar, 1/160 AMA, a-β2GPI (IgM)
25M/75HypertensionPOSFever, cough, dyspnoea9Diffuse infiltrates and ground glassDeathNoYesANA 1/320 speckled cytoplasmic, a-CL (IgG), a-β2GPI (IgM)
26F/82HypertensionPOSFever, cough, dyspnoea8Diffuse infiltrates and ground glassDeathNoNoANA 1/160 fine speckled nucleolar, 1/160 AMA, a-β2GPI (IgG+IgM)
27M/55HypertensionPOSFever, cough, fatigue8Diffuse infiltrates and ground glassAliveNoNoa-β2GPI (IgM)
28M/64Hypertension, dyslipidaemiaPOSFever, dyspnoea7Diffuse infiltrates and ground glassAliveNoYesNEG
29M/59NonePOSFever, diarrhoea2Diffuse infiltratesAliveNoYesa-β2GPI (IgG+IgM)
  • a-CL, anti-cardiolipin; AMA, anti-mitochondrial antibodies; ANA, antinuclear antibody; ANCA, anti-neutrophil cytoplasmic antibody; aPPT, activated Partial Thromboplastin Time; CCP, cyclic citrullinated peptide; ICU, intensive care unit; NEG, negative; POS, positive; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SOFA, sequential organ failure assessment.