RA associations of 19 loci in a meta-analysis
| Variant | Chr:Pos* | Gene† | Cohort #1 | Cohort #2 | Meta-analysis | ||||
| OR (95% CI)‡ | P value | OR (95% CI)‡ | P value | OR (95% CI)‡ | pmeta | pHet§ | |||
| rs11464953 | 1:17 645 185 | PADI4 | 1.23 (1.16–1.29) | 1.5×10−13 | 1.25 (1.12–1.40) | 8.9×10−5 | 1.23 (1.17–1.29) | 7.0×10−16 | 0.73 |
| rs148363003 | 1:160 443 973 | SLAMF6 | 1.63 (1.39–1.92) | 3.5×10−9 | 1.59 (1.12–2.27) | 1.0×10−2 | 1.62 (1.39–1.89) | 5.1×10−10 | 0.91 |
| rs11889341 | 2:191 943 742 | STAT4 | 1.21 (1.14–1.28) | 6.3×10−11 | 1.26 (1.12–1.41) | 1.3×10−4 | 1.22 (1.15–1.28) | 2.9×10−13 | 0.57 |
| rs117605225 | 4:78 508 197 | CXCL13 | 0.66 (0.57–0.76) | 1.6×10−8 | 0.59 (0.40–0.87) | 7.8×10−3 | 0.65 (0.56–0.75) | 1.9×10−9 | 0.63 |
| rs112062732 | 6:32 453 936 | HLA-DRB1 | 2.38 (2.25–2.52) | 1.1×10−193 | 2.79 (2.45–3.19) | 1.6×10−52 | 2.44 (2.31–2.58) | 5.5×10−227 | 0.034 |
| rs1044690 | 6:44 245 241 | NFKBIE | 1.19 (1.12–1.27) | 1.4×10−8 | 1.20 (1.06–1.37) | 4.6×10−3 | 1.20 (1.13–1.27) | 9.0×10−10 | 0.92 |
| rs9494893 | 6:138 223 490 | TNFAIP3 | 1.40 (1.27–1.55) | 4.7×10−11 | 1.15 (0.92–1.45) | 0.23 | 1.36 (1.23–1.49) | 3.5×10−10 | 0.13 |
| rs3093019 | 6:167 539 655 | CCR6 | 0.83 (0.78–0.87) | 2.3×10−12 | 0.84 (0.75–0.94) | 2.0×10−3 | 0.83 (0.79–0.87) | 1.4×10−13 | 0.85 |
| rs113066392 | 7:74 026 152 | GTF2IRD1 | 1.46 (1.35–1.57) | 6.3×10−22 | 1.22 (0.95–1.57) | 0.12 | 1.43 (1.33–1.55) | 1.3×10−20 | 0.20 |
| rs71508903 | 10:63 779 871 | ARID5B | 1.27 (1.19–1.36) | 2.9×10−13 | 1.12 (0.98–1.28) | 0.11 | 1.24 (1.17–1.32) | 2.4×10−12 | 0.092 |
| rs360136 | 11:9 773 517 | SWAP70 | 1.14 (1.08–1.20) | 1.4×10−6 | 1.31 (1.18–1.46) | 1.2×10−6 | 1.17 (1.11–1.23) | 4.5×10−10 | 0.026 |
| rs78894077 | 12:111 856 673 | SH2B3 | 1.30 (1.19–1.43) | 3.6×10−8 | 1.42 (1.10–1.83) | 7.2×10−3 | 1.32 (1.20–1.45) | 3.9×10−9 | 0.56 |
| rs111597524 | 14:35 861 800 | NFKBIA | 1.18 (1.12–1.26) | 1.3×10−8 | 1.15 (1.01–1.31) | 3.5×10−2 | 1.18 (1.12–1.24) | 5.3×10−9 | 0.68 |
| rs194757 | 14:69 213 851 | ZFP36L1 | 0.87 (0.83–0.92) | 2.9×10−6 | 0.81 (0.72–0.91) | 3.4×10−4 | 0.86 (0.82–0.91) | 2.5×10−8 | 0.24 |
| rs2841269 | 14:105 386 149 | PLD4 | 0.80 (0.76–0.85) | 5.9×10−15 | 0.82 (0.72–0.92) | 7.5×10−4 | 0.80 (0.76–0.85) | 2.4×10−16 | 0.77 |
| rs8032939 | 15:38 834 033 | RASGRP1 | 0.84 (0.80–0.89) | 1.6×10−10 | 0.93 (0.83–1.04) | 0.18 | 0.86 (0.81–0.90) | 9.5×10−10 | 0.13 |
| rs1547233 | 21:26 769 507 | LINC00158 | 1.17 (1.10–1.24) | 8.4×10−8 | 1.18 (1.05–1.33) | 6.3×10−3 | 1.17 (1.11–1.24) | 6.4×10−9 | 0.92 |
| rs2049985 | 22:39 756 650 | SYNGR1 | 0.78 (0.72–0.85) | 1.2×10−9 | 0.89 (0.75–1.05) | 0.17 | 0.80 (0.74–0.86) | 4.1×10−9 | 0.20 |
| rs1059702 | X:153 284 192 | IRAK1 | 0.86 (0.81–0.91) | 8.2×10−7 | 0.74 (0.65–0.84) | 3.3×10−6 | 0.84 (0.79–0.89) | 4.9×10−10 | 0.038 |
*Based on hg19.
†Novel RA loci are indicated in bold.
‡Frequencies, ORs and CIs for EAs.
§ P values for cross-cohort association heterogeneity (pHet) were calculated by Cochrane’s Q tests.
Chr, chromosome; EAs, effect alleles; Freq, frequency; NEA, non-effect allele; Pos, Position; RA, rheumatoid arthritis.