Baseline characteristics of patients with and without rheumatoid arthritis examined by coronary angiography from 2003 to 2016 stratified by presence of coronary artery disease
| No RA, no CAD (n=48517) | RA, no CAD (n=671) | No RA, CAD (n=75082) | RA, CAD (n=1061) | |||||
| n | % | n | % | n | % | n | % | |
| Mean age±SD | 60.5 years±12.4 | 65.5 years±10.9 | 65.9±11.3 | 68.9±10.1 | ||||
| Female | 23 996 | 49.5 | 447 | 66.6 | 22 573 | 30.1 | 562 | 53.0 |
| Active smoker* | 10 297 | 21.2 | 99 | 14.8 | 22 543 | 30.0 | 263 | 24.8 |
| Mean body mass index±SD* | 27.4 kg/m2±5.4 | 26.4 kg/m2±5.3 | 27.2 kg/m2±4.7 | 26.2 kg/m2±4.8 | ||||
| Comorbidity† | ||||||||
| Hypertension | 25 268 | 52.1 | 387 | 57.7 | 44 143 | 58.8 | 682 | 64.3 |
| Heart failure | 7485 | 15.4 | 132 | 19.7 | 12 584 | 16.8 | 235 | 22.1 |
| Myocardial infarction, 0–30 days after CAG | 1201 | 2.5 | 23 | 3.4 | 22 095 | 29.4 | 313 | 29.5 |
| Ischaemic stroke | 834 | 1.7 | 20 | 3.0 | 1952 | 2.6 | 39 | 3.7 |
| Transient ischaemic attack | 1157 | 2.4 | 24 | 3.6 | 2034 | 2.7 | 42 | 4.0 |
| Peripheral artery disease | 1186 | 2.4 | 24 | 3.6 | 4666 | 6.2 | 94 | 8.9 |
| Atrial fibrillation | 7802 | 16.1 | 123 | 18.3 | 9.448 | 12.6 | 182 | 17.2 |
| Diabetes | 5937 | 12.2 | 84 | 12.5 | 13 095 | 17.4 | 179 | 16.9 |
| Comedication | ||||||||
| Aspirin | 25 504 | 52.6 | 363 | 54.1 | 63 420 | 84.5 | 874 | 82.4 |
| ADP-inhibitor | 2854 | 5.9 | 62 | 9.2 | 41.926 | 55.8 | 612 | 57.7 |
| Vitamin K-antagonist | 6671 | 13.7 | 107 | 15.9 | 7135 | 9.5 | 125 | 11.8 |
| Direct oral anticoagulants | 1229 | 2.5 | 29 | 4.3 | 1605 | 2.1 | 31 | 2.9 |
| Statin | 22 536 | 46.4 | 283 | 42.2 | 64 911 | 86.5 | 876 | 82.6 |
| Extent of coronary artery disease | ||||||||
| 0 VD | 48 517 | 100 | 671 | 100 | – | – | – | – |
| Non-obstructive VD | – | – | – | – | 12 549 | 16.7 | 209 | 19.7 |
| 1 VD | – | – | – | – | 31 794 | 42.3 | 429 | 40.4 |
| 2 VD | – | – | – | – | 16 420 | 21.9 | 211 | 19.9 |
| 3 VD | – | – | – | – | 14 319 | 19.1 | 212 | 20.0 |
| Procedural priority | ||||||||
| Acute | 3633 | 7.5 | 52 | 7.7 | 18 924 | 25.2 | 268 | 25.3 |
| Subacute | 10 864 | 22.4 | 142 | 21.2 | 19 411 | 25.9 | 288 | 27.1 |
| Elective | 34 020 | 70.1 | 477 | 71.1 | 36 746 | 48.9 | 505 | 47.6 |
| Referral indication | ||||||||
| STEMI | 1967 | 4.1 | 30 | 4.5 | 16 784 | 22.4 | 241 | 22.7 |
| NSTEMI | 3767 | 7.8 | 50 | 7.5 | 13 697 | 18.2 | 215 | 20.3 |
| Unstable AP | 1614 | 3.3 | 21 | 3.1 | 2224 | 3.0 | 29 | 2.7 |
| Stable AP | 20 220 | 41.7 | 251 | 37.4 | 27 624 | 36.8 | 339 | 32.0 |
| Arrhythmia | 2277 | 4.7 | 31 | 4.6 | 1591 | 2.1 | 24 | 2.3 |
| Valve disease | 6105 | 12.6 | 101 | 15.1 | 4757 | 6.3 | 72 | 6.8 |
| Cardiomyopathy | 4500 | 9.3 | 77 | 11.5 | 3066 | 4.1 | 57 | 5.4 |
| Other | 8067 | 16.6 | 110 | 16.4 | 5339 | 7.1 | 84 | 7.9 |
*Smoking status missing in 10.0% of patients. Body mass index missing in 14.4% of patients.
†Defined as either discharge diagnosis or outpatient visit diagnosis (30 days prior to 30 days after index CAG)
ADP, adenosine diphosphate; AP, angina pectoris; CAD, coronary artery disease; CAG, coronary angiography; NSTEMI, non-ST segment elevation myocardial infarction; RA, rheumatoid arthritis; STEMI, ST segment elevation myocardial infarction; VD, vessel disease.