Table 1

Study sample characteristics: baseline values and change over follow-up (n=600)

Mean (SD)
Age62 (8.9)
Female (%)59%
African-American (%)18%
BMI (kg/m2)31 (4.8)*
Depressive symptoms (CESD)10%†
Kellgren and Lawrence Grade
 00%
 112.5%
 251.0%
 336.5%
WOMAC pain score baseline (range 0 to 20)2.4 (3.1)
 Change, baseline to 24 months0.62 (3.4)
 Change, baseline to 36 months0.93 (3.7)†
Cartilage thickness (mm), medial tibiofemoral compartment
 Baseline (range 1 to 8.6)3.3 (0.61)
 Change, baseline to 24 months (range −2 to 2)−0.10 (0.21)*
Cartilage thickness score (MOAKS)
 Baseline score (range 0 to 42)2.8 (2.8)
 Change, baseline to 24 months (range ±42)0.79 (1.56)
Synovitis score (MOAKS)
 Baseline (range 0–6)1.53 (1.19)
 Change, baseline to 24 months (range ±6)0.23 (0.88)
BML size summary score (MOAKS)
 Baseline (range 0 to 45)3.78 (2.79)
 Change, baseline to 24 months (range ±45)−0.45 (2.34)*
  • Values are mean(SD) unless otherwise specified.

  • *n=599.

  • †n=596.

  • BMI, body mass index; BML, bone marrow lesion; CESD, Center for Epidemiologic Studies Depression Scale; MOAKS, MRI Osteoarthritis Knee Score; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.