Table 2

Association of cartilage thickness loss over 24 months with change in WOMAC knee pain over 24 or 36 months

Outcome over 24 months
Mean change in WOMAC knee pain over 24 months*
(95% CI)
Outcome over 36 months
Mean change in WOMAC knee pain over 36 months*
(95% CI)
Exposure: 0.1 mm cartilage thickness loss over 24 months0.32 (0.21 to 0.44)†
p<0.0001
0.19 (0.07 to 0.32)†
p=0.0025
BML at baseline (size summary score across 15 regions)0.10 (0.00 to 0.19)
p=0.04
0.18 (0.08 to 0.28)
p=0.0005
Synovitis at baseline (summary score)0.03 (−0.18 to 0.24)
p=0.80
−0.05 (−0.28 to 0.18)
p=0.66
Exposure: 0.05 mm cartilage thickness loss over 24 months0.16 (0.10 to 0.22)†
p<0.0001
0.10 (0.03 to 0.16)†
p=0.0025
BML at baseline (size summary score across 15 regions)0.10 (0.00 to 0.19)
p=0.04
0.18 (0.08 to 0.28)
p=0.0005
Synovitis at baseline (summary score)0.03 (−0.18 to 0.24)
p=0.80
−0.05 (−0.28 to 0.18)
p=0.66
  • Positive(+) beta coefficient indicates an increase in WOMAC pain.

  • *Model for each exposure and outcome: exposure +standard set of covariates (baseline age, sex, BMI, race, depressive symptoms and pain)+baseline BML score +baseline synovitis score.

  • †Values are unstandardised regression coefficients representing mean change in WOMAC knee pain over 24 or 36 months.

  • BML, bone marrow lesion; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.