Sensitivity, specificity, positive and negative predictive values of different remission definitions in identifying patients without damage accrual throughout the follow-up
| PDN ≤5 mg/day | PGA <0.5 | cSLEDAI=0 | PGA <0.5 plus PDN ≤5 mg/day | cSLEDAI=0 plus PGA <0.5 | cSLEDAI=0 plus PDN ≤5 mg/day | cSLEDAI=0 plus PGA <0.5 plus PDN ≤5 mg/day | |
| Sensitivity | 82.4 (78.5 to 85.9) | 66.2 (61.6 to 70.6) | 79.2 (75.1 to 83.0) | 62.6 (57.8 to 67.1) | 65.1 (60.4 to 69.5) | 71.2 (66.8 to 75.4) | 61.6 (56.9 to 66.2) |
| Specificity | 27.4 (21.5 to 34.0) | 58.2 (51.2 to 65.0) | 47.6 (40.7 to 54.6) | 62.5 (55.5 to 69.1) | 59.6 (52.6 to 66.3) | 53.9 (46.8 to 60.8) | 63.5 (56.5 to 70.0) |
| PPV | 70.5 (66.4 to 74.4) | 76.9 (72.3 to 81.1) | 76.1 (71.9 to 80.0) | 77.8 (73.1 to 82.1) | 77.2 (72.6 to 81.4) | 76.5 (72.1 to 80.5) | 78.0 (73.3 to 82.3) |
| NPV | 57.5 (48.6 to 66.0) | 55.0 (48.9 to 61.1) | 47.9 (40.6 to 55.3) | 55.8 (49.9 to 61.6) | 55.2 (49.2 to 61.2) | 52.9 (46.4 to 59.4) | 56.0 (50.2 to 61.7) |
Values and their 95% CI are reported.
cSLEDAI, clinical SLE Disease Activity Index; NPV, negative predictive value; PDN, prednisone-equivalent; PGA, physician global assessment; PPV, positive predictive value; SLE, systemic lupus erythematosus.