Association between the reason for discontinuation of the first TNFi and response to the second TNFi
| Reason to discontinue first TNFi* | Outcome for the second TNFi OR (95% CI) | ||||
|---|---|---|---|---|---|
| ASDAS-CII (N=135) | ASDAS-MII (N=135) | ASDAS-LDA (N=166) | ASDAS-ID (N=166) | BASDAI50 (N=147) | |
| (ref Primary failure) | |||||
| -Secondary failure | 1.9 (0.7;4.8) | 4.8 (1.3;18.2) | 1.2 (0.6;2.4) | 7.3 (1.9;27.7) | 1.4 (0.6;3.0) |
| -Adverse events | 1.5 (0.6;3.5) | 2.4 (0.6;9.6) | 0.9 (0.5;1.7) | 9.1 (2.5;33.3) | 1.1 (0.5;2.3) |
| -Other | 1.0 (0.3;3.8) | 1.7 (0.1;19.4) | 1.0 (0.4;2.4) | 7.7 (1.6;37.9) | 0.5 (0.1;1.7) |
*GEE models with the reason of discontinuation of the first TNFi as predictor (reference category: primary failure); all models adjusted for age, gender and C-reactive protein. OR in bold are statistically significant (p<0.05).