Parameter (%) | MTX Monotherapy | UPA 15 mg QD Monotherapy | UPA 30 mg QD Monotherapy |
---|---|---|---|
ACR20/50/70 | 50/39/26 | 71***/62***/47*** | 72***/67***/54*** |
DAS28(CRP) ≤3.2/<2.6 | 38/28 | 63***/52*** | 69***/61*** |
CDAI ≤10/≤2.8 | 42/19 | 60***/35*** | 69***/44*** |
Boolean Remission | 13 | 29*** | 33*** |
***, P <0.001 for differences between MTX and UPA 15 and UPA 30 mg groups.
MTX, methotrexate; UPA, upadacitinib; QD, once daily; ACR, American College of Rheumatology; DAS28(CRP), 28-joint disease activity index based on C-reactive protein; CDAI, clinical disease activity index.