| PBO | BIIB059 | OVERALL | ||||
|---|---|---|---|---|---|---|
| N=33 | 50 mg N=26 | 150 mg N=25 | 450 mg N=48 | Pooled N=99 | N=132 | |
| Any Event, n(%) | 18 (54.5) | 17 (65.4) | 12 (48) | 33 (68.8) | 62 (62.6) | 80 (60.6) |
| Severity | ||||||
| Mild | 11 (33.3) | 11 (42.3) | 8 (32.0) | 19 (39.6) | 38 (38.4) | 49 (37.1) |
| Moderate | 4 (12.1) | 6 (23.1) | 3 (12.0) | 12 (25.0) | 21 (21.2) | 25 (18.9) |
| Severe | 3 (9.1) | 0 | 1 (4.0) | 2 (4.2) | 3 (3.0) | 6 (4.5) |
| Related events | 6 (18.2) | 9 (34.6) | 4 (16.0) | 16 (33.3) | 29 (29.3) | 35 (26.5) |
| Serious events | 2 (6.1) | 0 | 3 (12.0) | 2 (4.2) | 5 (5.1) | 7 (5.3) |
| Related serious events | 1 (3.0) | 0 | 1 (4.0) | 1 (2.1) | 2 (2.0) | 3 (2.3) |
| Events leading to drug withdrawal | 0 | 1 (3.8) | 1 (4.0) | 1 (2.1) | 3 (3.0) | 3 (2.3) |
| Events leading to study withdrawal | 0 | 0 | 0 | 1 (2.1) | 1 (1.0) | 1 (0.8) |
| Fatal events | 0 | 0 | 0 | 0 | 0 | 0 |