Table 1
Group1Group2Group3Group4
All-cause Mortality TramadolNaproxenTramadolDiclofenacTramadolCox-2 inhibitorTramadolCodeine
OA (n)13798137981767517675170391703978137813
Death (n)296246439345402267168199
Rate (/1000 PY)21.517.824.819.523.615.721.525.5
HR (95% CI)1.2 (1.0-1.4)1.01.3 (1.1-1.5)1.01.5 (1.3-1.8)1.00.8 (0.7-1.0)1.0
CVDOA (n)11708117081492414924147791477968096809
CVD (n)309319410349404353156164
Rate (/1000 PY)26.427.327.523.427.323.922.924.1
HR (95% CI)1.0 (0.9-1.1)1.01.2 (1.1-1.3)1.01.2 (1.0-1.3)1.00.9 (0.8-1.1)1.0
VTEOA (n)13472134721723017230166991669976607660
VTE (n)4137604070402830
Rate (/1000 PY)3.02.83.52.34.22.43.73.9
HR (95% CI)1.2 (0.9-1.6)1.01.5 (1.1-1.9)1.01.7 (1.3-2.3)1.01.0 (0.7-1.4)1.0
HFxOA (n)13378133781721617216166701667075937593
HFx (n)6649885991603540
Rate (/1000 PY)5.03.75.13.45.53.64.65.3
HR (95% CI)1.4 (1.0-1.8)1.01.5 (1.2-1.9)1.01.5 (1.2-1.9)1.00.9 (0.7-1.2)1.0