| Group1 | Group2 | Group3 | Group4 |
|---|
| All-cause Mortality | | Tramadol | Naproxen | Tramadol | Diclofenac | Tramadol | Cox-2 inhibitor | Tramadol | Codeine |
| OA (n) | 13798 | 13798 | 17675 | 17675 | 17039 | 17039 | 7813 | 7813 |
| Death (n) | 296 | 246 | 439 | 345 | 402 | 267 | 168 | 199 |
| Rate (/1000 PY) | 21.5 | 17.8 | 24.8 | 19.5 | 23.6 | 15.7 | 21.5 | 25.5 |
| HR (95% CI) | 1.2 (1.0-1.4) | 1.0 | 1.3 (1.1-1.5) | 1.0 | 1.5 (1.3-1.8) | 1.0 | 0.8 (0.7-1.0) | 1.0 |
| CVD | OA (n) | 11708 | 11708 | 14924 | 14924 | 14779 | 14779 | 6809 | 6809 |
| CVD (n) | 309 | 319 | 410 | 349 | 404 | 353 | 156 | 164 |
| Rate (/1000 PY) | 26.4 | 27.3 | 27.5 | 23.4 | 27.3 | 23.9 | 22.9 | 24.1 |
| HR (95% CI) | 1.0 (0.9-1.1) | 1.0 | 1.2 (1.1-1.3) | 1.0 | 1.2 (1.0-1.3) | 1.0 | 0.9 (0.8-1.1) | 1.0 |
| VTE | OA (n) | 13472 | 13472 | 17230 | 17230 | 16699 | 16699 | 7660 | 7660 |
| VTE (n) | 41 | 37 | 60 | 40 | 70 | 40 | 28 | 30 |
| Rate (/1000 PY) | 3.0 | 2.8 | 3.5 | 2.3 | 4.2 | 2.4 | 3.7 | 3.9 |
| HR (95% CI) | 1.2 (0.9-1.6) | 1.0 | 1.5 (1.1-1.9) | 1.0 | 1.7 (1.3-2.3) | 1.0 | 1.0 (0.7-1.4) | 1.0 |
| HFx | OA (n) | 13378 | 13378 | 17216 | 17216 | 16670 | 16670 | 7593 | 7593 |
| HFx (n) | 66 | 49 | 88 | 59 | 91 | 60 | 35 | 40 |
| Rate (/1000 PY) | 5.0 | 3.7 | 5.1 | 3.4 | 5.5 | 3.6 | 4.6 | 5.3 |
| HR (95% CI) | 1.4 (1.0-1.8) | 1.0 | 1.5 (1.2-1.9) | 1.0 | 1.5 (1.2-1.9) | 1.0 | 0.9 (0.7-1.2) | 1.0 |