Body mass index-associated changes of cartilage degradation and subchondral bone (SCB) remodelling
| Unadjusted | Age and sex adjusted | |||||
| β (95% CI) | P value | β (95% CI) | P value | |||
| Predominant | Cartilage evaluation | OARSI | −0.046 (−0.076 to −0.016) | 0.003 | −0.048 (−0.081 to −0.016) | 0.004 |
| Bone formation | OV/BV (%) | 0.001 (0.000 to 0.001) | 0.019 | 0.001 (0.000 to 0.001) | 0.014 | |
| OS/BS (%) | 0.004 (0.001 to 0.007) | 0.022 | 0.004 (0.001 to 0.008) | 0.024 | ||
| O.Th (µm) | 0.327 (0.161 to 0.492) | 0.000 | 0.293 (0.112 to 0.454) | 0.002 | ||
| Bone resorption | ES/BS (%) | 0.000 (−0.001 to 0.000) | 0.349 | 0.000 (−0.001 to 0.000) | 0.254 | |
| ES/BV (mm2/mm3) | −0.003 (−0.009 to 0.002) | 0.228 | −0.004 (−0.010 to 0.002) | 0.178 | ||
| ES/TV (mm2/mm3) | −0.001 (−0.003 to 0.001) | 0.190 | −0.001 (−0.003 to 0.001) | 0.173 | ||
| OS/BV (mm2/mm3) | −0.148 (−0.015 to 0.069) | 0.199 | 0.032 (−0.015 to 0.079) | 0.181 | ||
| OS/ES | 0.776 (−0.080 to 1.632) | 0.075 | 0.788 (−0.171 to 1.747) | 0.106 | ||
| Medial | Cartilage evaluation | OARSI | −0.035 (−0.062 to −0.008) | 0.011 | −0.037 (−0.066 to −0.007) | 0.016 |
| Bone formation | OV/BV (%) | 0.001 (0.000 to 0.001) | 0.014 | −0.001 (0.000 to 0.001) | 0.011 | |
| OS/BS (%) | 0.004 (0.001 to 0.007) | 0.014 | 0.004 (0.001 to 0.008) | 0.015 | ||
| O.Th (µm) | 0.345 (0.181 to 0.510) | 0.000 | 0.311 (0.133 to 0.490) | 0.001 | ||
| Bone resorption | ES/BS (%) | 0.000 (0.000 to 0.000) | 0.579 | 0.000 (0.000 to 0.000) | 0.596 | |
| ES/BV (mm2/mm3) | −0.002 (−0.007 to 0.002) | 0.237 | −0.002 (−0.007 to 0.002) | 0.310 | ||
| ES/TV (mm2/mm3) | −0.001 (−0.002 to 0.001) | 0.396 | −0.001 (−0.002 to 0.001) | 0.423 | ||
| OS/BV (mm2/mm3) | 0.030 (−0.012 to 0.071) | 0.163 | 0.036 (−0.011 to 0.082) | 0.399 | ||
| OS/ES | 0.772 (−0.084 to 1.629) | 0.077 | 0.764 (−0.197 to 1.724) | 0.118 | ||
| Lateral | Cartilage evaluation | OARSI | −0.033 (−0.062 to −0.003) | 0.030 | −0.033 (−0.064 to −0.001) | 0.044 |
| Bone formation | OV/BV (%) | 0.001 (9.915E−5 to 0.001) | 0.020 | 0.001 (0.000 to 0.001) | 0.009 | |
| OS/BS (%) | 0.004 (0.001 to 0.007) | 0.024 | 0.004 (0.001 to 0.008) | 0.017 | ||
| O.Th (µm) | 0.320 (0.161 to 0.479) | 0.000 | 0.319 (0.143 to 0.495) | 0.001 | ||
| Bone resorption | ES/BS (%) | 0.000 (−0.001 to 0.000) | 0.226 | 0.000 (−0.001 to 0.000) | 0.235 | |
| ES/BV (mm2/mm3) | −0.004 (−0.010 to 0.001) | 0.137 | −0.004 (−0.011 to 0.002) | 0.167 | ||
| ES/TV (mm2/mm3) | −0.001 (−0.003 to 0.001) | 0.153 | −0.001 (−0.003 to 0.001) | 0.199 | ||
| OS/BV (mm2/mm3) | 0.027 (−0.016 to 0.069) | 0.218 | 0.034 (−0.013 to 0.081) | 0.149 | ||
| OS/ES | 0.768 (−0.087 to 1.632) | 0.078 | 0.823 (−0.119 to 1.766) | 0.086 | ||
Dependent variable: histomorphomectric parameters (continuous variable). Independent variable: BMI (kg/m2, continuous variable). Method: linear regression.
ES/BS, per cent eroded surface; ES/BV, specific eroded surface; ES/TV, eroded surface in bone tissue volume; OARSI, Osteoarthritis Research Society International Grading; OS/BS, per cent osteoid surface; OS/BV, specific osteoid surface; OS/ES, the ratio of osteoid surface to eroded surface; O.Th, thickness of osteoid; OV/BV, per cent osteoid volume.