Table 3

Body mass index-associated changes of cartilage degradation and subchondral bone (SCB) remodelling

UnadjustedAge and sex adjusted
β (95% CI)P valueβ (95% CI)P value
PredominantCartilage evaluationOARSI−0.046 (−0.076 to −0.016)0.003−0.048 (−0.081 to −0.016)0.004
Bone formationOV/BV (%)0.001 (0.000 to 0.001)0.0190.001 (0.000 to 0.001)0.014
OS/BS (%)0.004 (0.001 to 0.007)0.0220.004 (0.001 to 0.008)0.024
O.Th (µm)0.327 (0.161 to 0.492)0.0000.293 (0.112 to 0.454)0.002
Bone resorptionES/BS (%)0.000 (−0.001 to 0.000)0.3490.000 (−0.001 to 0.000)0.254
ES/BV (mm2/mm3)−0.003 (−0.009 to 0.002)0.228−0.004 (−0.010 to 0.002)0.178
ES/TV (mm2/mm3)−0.001 (−0.003 to 0.001)0.190−0.001 (−0.003 to 0.001)0.173
OS/BV (mm2/mm3)−0.148 (−0.015 to 0.069)0.1990.032 (−0.015 to 0.079)0.181
OS/ES0.776 (−0.080 to 1.632)0.0750.788 (−0.171 to 1.747)0.106
MedialCartilage evaluationOARSI−0.035 (−0.062 to −0.008)0.011−0.037 (−0.066 to −0.007)0.016
Bone formationOV/BV (%)0.001 (0.000 to 0.001)0.014−0.001 (0.000 to 0.001)0.011
OS/BS (%)0.004 (0.001 to 0.007)0.0140.004 (0.001 to 0.008)0.015
O.Th (µm)0.345 (0.181 to 0.510)0.0000.311 (0.133 to 0.490)0.001
Bone resorptionES/BS (%)0.000 (0.000 to 0.000)0.5790.000 (0.000 to 0.000)0.596
ES/BV (mm2/mm3)−0.002 (−0.007 to 0.002)0.237−0.002 (−0.007 to 0.002)0.310
ES/TV (mm2/mm3)−0.001 (−0.002 to 0.001)0.396−0.001 (−0.002 to 0.001)0.423
OS/BV (mm2/mm3)0.030 (−0.012 to 0.071)0.1630.036 (−0.011 to 0.082)0.399
OS/ES0.772 (−0.084 to 1.629)0.0770.764 (−0.197 to 1.724)0.118
LateralCartilage evaluationOARSI−0.033 (−0.062 to −0.003)0.030−0.033 (−0.064 to −0.001)0.044
Bone formationOV/BV (%)0.001 (9.915E−5 to 0.001)0.0200.001 (0.000 to 0.001)0.009
OS/BS (%)0.004 (0.001 to 0.007)0.0240.004 (0.001 to 0.008)0.017
O.Th (µm)0.320 (0.161 to 0.479)0.0000.319 (0.143 to 0.495)0.001
Bone resorptionES/BS (%)0.000 (−0.001 to 0.000)0.2260.000 (−0.001 to 0.000)0.235
ES/BV (mm2/mm3)−0.004 (−0.010 to 0.001)0.137−0.004 (−0.011 to 0.002)0.167
ES/TV (mm2/mm3)−0.001 (−0.003 to 0.001)0.153−0.001 (−0.003 to 0.001)0.199
OS/BV (mm2/mm3)0.027 (−0.016 to 0.069)0.2180.034 (−0.013 to 0.081)0.149
OS/ES0.768 (−0.087 to 1.632)0.0780.823 (−0.119 to 1.766)0.086
  • Dependent variable: histomorphomectric parameters (continuous variable). Independent variable: BMI (kg/m2, continuous variable). Method: linear regression.

  • ES/BS, per cent eroded surface; ES/BV, specific eroded surface; ES/TV, eroded surface in bone tissue volume; OARSI, Osteoarthritis Research Society International Grading; OS/BS, per cent osteoid surface; OS/BV, specific osteoid surface; OS/ES, the ratio of osteoid surface to eroded surface; O.Th, thickness of osteoid; OV/BV, per cent osteoid volume.