Dactylitis MRI total and partial scores
| Dactylitis total score | Baseline | Week 24 | |||||||||
| Population (n=36) | GLM+MTX (n=18) | PLB+MTX (n=18) | P value* | Population (n=36) | GLM+MTX (n=18) | PLB+MTX (n=18) | P value† | Median change GLM+MTX | Median change PLB+MTX | P value‡ | |
| Median (IQR) | 8 (7) | 8.5 (7) | 8.0 (10) | 0.696 | 3.5 (4) | 2 (3) | 5.5 (3) | 0.017 | −5.5 (4.8) | −3.5 (6.5) | 0.273 |
| (observed range) | 2 to 20 | 2 to 17 | 2 to 20 | 0 to 17 | 0 to 17 | 0 to 7 | −14 to 0 | −13 to 2 | |||
| Dactylitis partial scores | MCP/MTP | PIP | DIP | |||||||||
| GLM+MTX | PLB+MTX | GLM+MTX | PLB+MTX | GLM+MTX | PLB+MTX | |||||||
| Baseline | Change | Baseline | Change | Baseline | Change | Baseline | Change | Baseline | Change | Baseline | Change | |
| Synovitis, mean | 0.56 | −0.28 | 0.78 | −0.17 | 0.78 | −0.61* | 0.5 | −0.22 | 0.38 | −0.31 | 0.31 | 0.12 |
| (observed range) | (0 to 1) | (−1 to 1) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (0 to 1) |
| Bone oedema, mean | 0.44 | −0.28 | 0.5 | −0.39 | 0.67 | −0.56§ | 0.44 | −0.22 | 0.31 | −0.23 | 0.38 | −0.06 |
| (observed range) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 1) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) |
| Subcutaneous oedema, mean | 0.5 | −0.44 | 0.67 | −0.39 | 0.78 | −0.61 | 0.5 | −0.33 | 0.38 | −0.31 | 0.5 | −0.12 |
| (observed range) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (-1 to 1) |
| Flexor tenosynovitis, mean | 0.33 | −0.22 | 0.56 | −0.17 | 0.44 | −0.22 | 0.44 | −0.17 | 0.23 | −0.08 | 0.25 | −0.19 |
| (observed range) | (0 to 1) | (−1 to 1) | (0 to 1) | (−1 to 1) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 1) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) |
| Extensor paratenonitis, mean | 0 | 0 | 0.11 | −0.11 | 0 | 0.06 | 0.11 | −0.11 | 0.15 | −0.08 | 0.06 | −0.06 |
| (observed range) | (0 to 0) | (0 to 0) | (0 to 1) | (−1 to 0) | (0 to 0) | (0 to 1) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) |
| Volar and palmar/plantar plate enhancement, mean | 0.5 | −0.33 | 0.59 | −0.47 | 0.5 | −0.44 | 0.44 | −0.28 | 0.23 | −0.15 | 0.31 | −0.12 |
| (observed range) | (0 to 1) | (−1 to 1) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 1) |
| Collateral ligament enhancement, mean | 0.39 | −0.28 | 0.67 | −0.33 | 0.39 | −0.28 | 0.44 | −0.28 | 0.23 | −0.15 | 0.38 | −0.12 |
| (observed range) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (−1 to 0) |
| Erosions, mean | 0.39 | 0 | 0.44 | 0 | 0.61 | −0.06 | 0.28 | 0 | 0.31 | 0 | 0.5 | 0 |
| (observed range) | (0 to 1) | (−1 to 1) | (0 to 1) | (0 to 0) | (0 to 1) | (−1 to 0) | (0 to 1) | (0 to 0) | (0 to 1) | (0 to 0) | (0 to 1) | (0 to 0) |
*Differences in the dactylitis total score at baseline, between treatment arms.
†Differences in the dactylitis total score at week 24, between treatment arms.
‡Differences in the median change of the dactylitis total score from baseline to week 24, between treatment arms.
§Differences in the mean change of the dactylitis partial score from baseline to week 24, between treatment arms. p<0.05.
DIP, distal interphalangeal joints; GLM, golimumab; MCP/MTP, metacarpal/metatarsophalangeal joints; MTX, methotrexate; PIP, proximal interphalangeal joints; PLB, placebo.