Table 3

Multivariable-adjusted association of allopurinol or febuxostat use and other risk factors with incident hypersensitivity reactions

Multivariable-adjusted (model 1)*Multivariable-adjusted (model 2)†
Hr (95% CI)P valueHr (95% CI)P value
Age (years)
 65 to <75RefRef
 75 to <850.98 (0.86 to 1.13)0.821.02 (0.89 to 1.18)0.76
 ≥850.92 (0.76 to 1.10)0.360.90 (0.73 to 1.10)0.29
Sex
 MaleRefRef
 Female 1.28 (1.13 to 1.45) 0.0001 1.28 (1.12 to 1.46) 0.0004
Race
 WhiteRefRef
 Black0.99 (0.82 to 1.19)0.881.02 (0.84 to 1.25)0.81
 Other1.05 (0.85 to 1.30)0.661.07 (0.84 to 1.35)0.59
Charlson-Romano score, per unit change1.01 (0.99 to 1.03)0.361.03 (1.00 to 1.05)0.037
Statins0.94 (0.73 to 1.20)0.610.99 (0.75 to 1.31)0.94
Beta-blockers1.06 (0.84 to 1.34)0.631.10 (0.84 to 1.44)0.51
Diuretics1.10 (0.88 to 1.38)0.391.16 (0.90 to 1.51)0.26
ACE inhibitors0.91 (0.69 to 1.20)0.520.95 (0.70 to 1.30)0.75
ColchicineRefRef
Allopurinol 1.32 (1.10 to 1.60) 0.003 1.12 (0.92 to 1.36)0.28
Febuxostat 1.54 (1.12 to 2.12) 0.008 1.44 (1.04 to 2.00) 0.031
Allopurinol+colchicine1.05 (0.80 to 1.39)0.731.07 (0.81 to 1.43)0.62
Allopurinol+febuxostat0.91 (0.29 to 2.85)0.871.06 (0.34 to 3.34)0.92
Febuxostat+colchicine 2.17 (1.18 to 3.99) 0.013 2.23 (1.21 to 4.11) 0.01
Allopurinol+febuxostat+colchicine2.33 (0.58 to 9.39)0.232.70 (0.67 to 10.91)0.16
  • Bold font represents statistically significant comparisons with a p-value <0.05.

  • *Model 1=colchicine/allopurinol/febuxostat exposure+age+race+gender+Charlson-Romano index score as continuous+beta-blockers+diuretics+ACE inhibitors+statins; #episodes in model=1038.

  • †Model 2=model 1 limited to patients with gout; #episodes in model=883.

  • Ref, referent category.