Table 1

Demographic and clinical characteristics of incident HSRs in people with allopurinol or febuxostat or colchicine exposure

All episodesHSR during the follow-upP value
YesNo
Total, N (episodes)66 178103865 140
Age, mean (SD)76.49 (7.42)76.3 (7.10)76.5 (7.42)0.42
Sex, N (%) 0.001
 Male33 132 (50.1%)465 (44.8%)32 667 (50.2%)
 Female33 046 (49.9%)573 (55.2%)32 473 (49.9%)
Race/Ethnicity, N (%)0.4
 White51 043 (77.1%)816 (78.6%)50 227 (77.1%)
 Black8981 (13.6%)129 (12.4%)8852 (13.6%)
 Hispanic1150 (1.7%)19 (1.8%)1131 (1.7%)
 Asian3441 (5.2%)48 (4.6%)3393 (5.2%)
 Native American150 (0.2%)0 (0.0%)150 (0.2%)
 Other/unknown1413 (2.1%)26 (2.5%)1387 (2.1%)
Region, N (%)0.18
 Midwest15 194 (23.0%)265 (25.5%)14 929 (22.9%)
 Northeast11 663 (17.6%)168 (16.2%)11 495 (17.7%)
 South27 503 (41.6%)430 (41.4%)27 073 (41.6%)
 West11 818 (17.9%)175 (16.9%)11 643 (17.9%)
Charlson-Romano* comorbidity score, mean (SD)2.59 (3.09)1.94 (2.94)2.61 (3.10) < 0.0001
Select Charlson-Romano score comorbidities†
 Myocardial infarction3157 (4.8%)31 (3.0%)3126 (4.8%) 0.001
 Diabetes19 727 (29.8%)225 (21.7%)19 502 (29.9%) < 0.0001
 Malignancy6009 (9.1%)84 (8.1%)5925 (9.1%)0.26
 Congestive heart failure14 282 (21.6%)177 (17.1%)14 105 (21.7%) 0.0003
 Moderate or severe liver disease133 (0.2%)0 (0%)133 (0.2%)0.15
 Moderate or severe renal disease14 983 (22.6%)175 (16.9%)14 808 (22.7%) < 0.0001
  • HSR, incident HSRs defined as per Wright et al with the occurrence of a new HSR with a clean baseline period of 365 days with no HSR. Bold font represents statistically significant comparisons with a p-value <0.05.

  • *Charlson-Romano comorbidity score was assessed for the baseline period for each episode. It is a validated measure of comorbidity that uses diagnosis codes for comorbidities for each inpatient and outpatient claim and dates from claims files. Comorbidities included diabetes, myocardial infarction, congestive heart failure, cerebrovascular disease, liver disease, pulmonary disease, peripheral vascular disease, rheumatic disease and so on.

  • †We selected six Charlson-Romano comorbidities a priori to assess their association with HSRs.

  • HSR, hypersensitivity reaction.